Erythropoietin and ferritin response in native highlanders aged 4–19 years from the Leh‐Ladakh region of India
Summary The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls,...
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| Published in | British journal of haematology Vol. 184; no. 2; pp. 263 - 268 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.01.2019
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| Abstract | Summary
The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. |
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| AbstractList | Summary
The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh-Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh-Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders.The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO, haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh-Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher (P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. The pivotal role of erythropoietin ( EPO ) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from Andes and Tibet. We assessed the relationship between EPO , haemoglobin and ferritin in 335 native highlanders (172 boys and 163 girls, aged 4 to 19 years) from Leh‐Ladakh, India, who had no history of travel to lowland areas. Complete blood counts, serum EPO and ferritin levels were measured. We stratified study subjects based on age, gender, pubertal status and analysed the EPO and ferritin levels between the stratified groups respectively. The mean EPO level in boys was lower than girls. The mean ferritin level in boys was significantly higher ( P = 0·013) than in girls. There was no significant variation in the EPO and ferritin levels amongst the various age groups in our study. Near normal EPO levels since childhood with a negative correlation with haemoglobin is suggestive of a robust adaptive mechanism to high altitude from the early years of life. Low ferritin levels are indicative of decreased iron stores in these native highlanders. |
| Author | Kumar, Suman Bhattachar, Srinivas A. Senee, Harikishan Nair, Velu Yanamadra, Sushma Varma, Neelam Yanamandra, Uday Das, Reena Das, Subrat K. Malhotra, Pankaj Varma, Subhash |
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| Cites_doi | 10.1152/jappl.1985.59.2.360 10.3357/ASEM.2085.2007 10.1007/s12288-018-0967-4 10.1152/japplphysiol.00535.2013 10.1182/blood-2010-08-299859 10.1152/jappl.1989.66.4.1561 10.1002/ajpa.1330730404 10.2165/00007256-199214050-00002 10.1016/S0022-2143(98)90091-9 10.1089/ham.2006.7.193 10.1016/j.resp.2007.03.006 10.1152/physrev.1992.72.2.449 10.1093/molbev/mst090 |
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| Copyright | 2018 British Society for Haematology and John Wiley & Sons Ltd 2018 British Society for Haematology and John Wiley & Sons Ltd. Copyright © 2019 John Wiley & Sons Ltd |
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| References | 2007; 158 2013; 29 2014; 116 1989; 66 2015; 5 1987; 73 2011; 117 2001 2011 2013; 30 2000; 72 2006; 7 1996 2018 2017 1992; 14 2001; 79 2007; 78 1985; 59 1992; 72 1998; 131 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 e_1_2_7_2_1 e_1_2_7_14_1 WHO (e_1_2_7_16_1) 2001 Beall C.M. (e_1_2_7_3_1) 2000; 72 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_22_1 Longo D.L. (e_1_2_7_8_1) 2011 e_1_2_7_21_1 Stevens S.F. (e_1_2_7_15_1) 1996 World Medical Association (e_1_2_7_18_1) 2001; 79 Wu T.Y. (e_1_2_7_20_1) 2013; 29 R Core Team (e_1_2_7_13_1) 2017 Norboo T. (e_1_2_7_10_1) 2015; 5 |
| References_xml | – year: 2011 – volume: 14 start-page: 289 year: 1992 end-page: 303 article-title: High‐altitude training. Aspects of haematological adaptation publication-title: Sports Medicine (Auckland, N. Z.) – volume: 131 start-page: 207 year: 1998 end-page: 214 article-title: Hypoxia‐inducible factor 1 and the molecular physiology of oxygen homeostasis publication-title: Journal of Laboratory and Clinical Medicine – volume: 73 start-page: 433 year: 1987 end-page: 438 article-title: Hemoglobin concentration of pastoral nomads permanently resident at 4850–5450 meters in Tibet publication-title: American Journal of Physical Anthropology – volume: 117 start-page: 2953 year: 2011 end-page: 2959 article-title: Modulation of hepcidin production during hypoxia‐induced erythropoiesis in humans in vivo: data from the HIGHCARE project publication-title: Blood – volume: 66 start-page: 1156 year: 1989 end-page: 1569 article-title: Different hematologic responses to hypoxia in Sherpas and Quechua Indians publication-title: Journal of Applied Physiology (1985) – volume: 78 start-page: 963 year: 2007 end-page: 967 article-title: Erythropoietin levels in lowlanders and high‐altitude natives at 3450 m publication-title: Aviation, Space and Environmental Medicine – volume: 158 start-page: 287 year: 2007 end-page: 297 article-title: Erythropoietin regulations in humans under different environmental and experimental conditions publication-title: Respiratory Physiology & Neurobiology – year: 2001 – volume: 30, start-page: 1889 year: 2013 end-page: 1898 article-title: Identification of a Tibetan‐specific mutation in the hypoxic gene EGLN1 and its contribution to high‐altitude adaptation publication-title: Molecular Biology and Evolution – year: 1996 – volume: 79 start-page: 373 year: 2001 end-page: 374 article-title: World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects publication-title: Bulletin of the World Health Organization – volume: 7 start-page: 193 year: 2006 end-page: 208 article-title: High altitude adaptation in Tibetans publication-title: High Altitude Medicine & Biology – volume: 116 start-page: 893 year: 2014 end-page: 904 article-title: Tibetans living at sea level have a hyporesponsive hypoxia‐inducible factor system and blunted physiological responses to hypoxia publication-title: Journal of Applied Physiology (1985) – volume: 59 start-page: 360 year: 1985 end-page: 364 article-title: Serum erythropoietin in humans at high altitude and its relation to plasma renin publication-title: Journal of Applied Physiology (1985) – year: 2018 article-title: Hematological Parameters in Native Highlanders of Ladakh Aged 4–19 Years publication-title: Indian Journal of Hematology and Blood Transfusion – year: 2017 – volume: 72 start-page: 449 year: 1992 end-page: 489 article-title: Erythropoietin: structure, control of production, and function publication-title: Physiological Reviews – volume: 72 start-page: 201 year: 2000 end-page: 228 article-title: Tibetan and Andean patterns of adaptation to high‐altitude hypoxia publication-title: Human Biology – volume: 5 start-page: e007026 year: 2015 article-title: Prevalence of hypertension at high altitude: cross‐sectional survey in Ladakh, Northern India 2007–2011 publication-title: British Medical Journal Open – volume: 29 start-page: 481 year: 2013 end-page: 493 article-title: A genetic adaptive pattern‐low hemoglobin concentration in the Himalayan highlanders publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi – volume-title: Claiming the High Ground: Sherpas, Subsistence, and Environmental Change in the Highest Himalaya year: 1996 ident: e_1_2_7_15_1 – volume: 79 start-page: 373 year: 2001 ident: e_1_2_7_18_1 article-title: World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects publication-title: Bulletin of the World Health Organization – ident: e_1_2_7_9_1 doi: 10.1152/jappl.1985.59.2.360 – ident: e_1_2_7_2_1 doi: 10.3357/ASEM.2085.2007 – volume: 29 start-page: 481 year: 2013 ident: e_1_2_7_20_1 article-title: A genetic adaptive pattern‐low hemoglobin concentration in the Himalayan highlanders publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi – volume-title: Harrison Principles of Internal Medicine year: 2011 ident: e_1_2_7_8_1 – ident: e_1_2_7_22_1 doi: 10.1007/s12288-018-0967-4 – ident: e_1_2_7_11_1 doi: 10.1152/japplphysiol.00535.2013 – volume: 72 start-page: 201 year: 2000 ident: e_1_2_7_3_1 article-title: Tibetan and Andean patterns of adaptation to high‐altitude hypoxia publication-title: Human Biology – ident: e_1_2_7_12_1 doi: 10.1182/blood-2010-08-299859 – ident: e_1_2_7_17_1 doi: 10.1152/jappl.1989.66.4.1561 – ident: e_1_2_7_4_1 doi: 10.1002/ajpa.1330730404 – ident: e_1_2_7_5_1 doi: 10.2165/00007256-199214050-00002 – volume: 5 start-page: e007026 year: 2015 ident: e_1_2_7_10_1 article-title: Prevalence of hypertension at high altitude: cross‐sectional survey in Ladakh, Northern India 2007–2011 publication-title: British Medical Journal Open – ident: e_1_2_7_14_1 doi: 10.1016/S0022-2143(98)90091-9 – ident: e_1_2_7_19_1 doi: 10.1089/ham.2006.7.193 – ident: e_1_2_7_6_1 doi: 10.1016/j.resp.2007.03.006 – ident: e_1_2_7_7_1 doi: 10.1152/physrev.1992.72.2.449 – ident: e_1_2_7_21_1 doi: 10.1093/molbev/mst090 – volume-title: R: A Language and Environment for Statistical Computing year: 2017 ident: e_1_2_7_13_1 – volume-title: Iron Deficiency Anaemia: Assessment, Prevention, and Control—A Guide for Program Managers. Geneva, Switzerland: World Health Organization; 2001 year: 2001 ident: e_1_2_7_16_1 |
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The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders... The pivotal role of erythropoietin ( EPO ) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from... The pivotal role of erythropoietin (EPO) in hypoxic adaptation has led to various studies assessing the EPO and ferritin response in native highlanders from... |
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| SubjectTerms | Children Children & youth Erythropoietin Ferritin haematology Hematology Hemoglobin highlanders Hypoxia India Ladakh |
| Title | Erythropoietin and ferritin response in native highlanders aged 4–19 years from the Leh‐Ladakh region of India |
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