Improved joint health in subjects with severe haemophilia A treated prophylactically with recombinant factor VIII Fc fusion protein

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia Vol. 24; no. 1; pp. 77 - 84
• Main Authors: Oldenburg, J., Kulkarni, R., Srivastava, A., Mahlangu, J. N., Blanchette, V. S., Tsao, E., Winding, B., Dumont, J., Jain, N.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2018
• Subjects: arthropathy; Bleeding; Coagulation factors; factor VIII; Factor VIII deficiency; Fc receptors; Fusion protein; haemarthrosis; haemophilia; Hemophilia; joint health; Prophylaxis; haemophilia; joint health; haemarthrosis; arthropathy; factor VIII; prophylaxis

Introduction Joint arthropathy is the long‐term consequence of joint bleeding in people with severe haemophilia. Aim This study assessed change in joint health over time in subjects receiving recombinant factor VIII Fc fusion protein (rFVIIIFc) prophylaxis. Methods ALONG is the phase 3 pivotal study...