Protective effect of resveratrol against pembrolizumab‐induced hepatotoxicity and neurotoxicity in male rats
The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the study were 28 male Sprague‐Dawley rats (3–4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at...
Saved in:
Published in | Journal of biochemical and molecular toxicology Vol. 37; no. 3; pp. e23263 - n/a |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Wiley Subscription Services, Inc
01.03.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the study were 28 male Sprague‐Dawley rats (3–4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at 5 mg/kg/day i.p. for a week. Group 3: Administered RSV orally at the dose of 20 mg/kg/day for 30 days by gavage. Group 4: Administered PEMB and RSV at 20 and 5 mg/kg/day RSV, respectively, for 30 days. The results of this study revealed that PEMB leads to a significant increase in thiobarbituric acid reactive substance (TBARS) levels and a significant decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities, and glutathione (GSH) levels in the liver and brain tissues. The decreased SOD, CAT, GPx activities, and GSH levels increased significantly following RSV treatment in Group 4. The PEMB treatment showed histopathological alterations associated with strong positive cysteinyl aspartic acid‐protease‐3 (caspase‐3) immunoreactivity, while RSV treatment reduced both the expression of caspase‐3 protein and the histopathological changes. RSV administration prevents the biochemical, immunological, and histological alterations induced by PEMB. It can be suggested that the lower caspase‐3 immunoreactivity in the PEMB + RSV group than in the PEMB group led to an inhibition of RSV on apoptosis. |
---|---|
AbstractList | The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the study were 28 male Sprague‐Dawley rats (3–4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at 5 mg/kg/day i.p. for a week. Group 3: Administered RSV orally at the dose of 20 mg/kg/day for 30 days by gavage. Group 4: Administered PEMB and RSV at 20 and 5 mg/kg/day RSV, respectively, for 30 days. The results of this study revealed that PEMB leads to a significant increase in thiobarbituric acid reactive substance (TBARS) levels and a significant decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities, and glutathione (GSH) levels in the liver and brain tissues. The decreased SOD, CAT, GPx activities, and GSH levels increased significantly following RSV treatment in Group 4. The PEMB treatment showed histopathological alterations associated with strong positive cysteinyl aspartic acid‐protease‐3 (caspase‐3) immunoreactivity, while RSV treatment reduced both the expression of caspase‐3 protein and the histopathological changes. RSV administration prevents the biochemical, immunological, and histological alterations induced by PEMB. It can be suggested that the lower caspase‐3 immunoreactivity in the PEMB + RSV group than in the PEMB group led to an inhibition of RSV on apoptosis. The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the study were 28 male Sprague‐Dawley rats (3–4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at 5 mg/kg/day i.p. for a week. Group 3: Administered RSV orally at the dose of 20 mg/kg/day for 30 days by gavage. Group 4: Administered PEMB and RSV at 20 and 5 mg/kg/day RSV, respectively, for 30 days. The results of this study revealed that PEMB leads to a significant increase in thiobarbituric acid reactive substance (TBARS) levels and a significant decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities, and glutathione (GSH) levels in the liver and brain tissues. The decreased SOD, CAT, GPx activities, and GSH levels increased significantly following RSV treatment in Group 4. The PEMB treatment showed histopathological alterations associated with strong positive cysteinyl aspartic acid‐protease‐3 (caspase‐3) immunoreactivity, while RSV treatment reduced both the expression of caspase‐3 protein and the histopathological changes. RSV administration prevents the biochemical, immunological, and histological alterations induced by PEMB. It can be suggested that the lower caspase‐3 immunoreactivity in the PEMB + RSV group than in the PEMB group led to an inhibition of RSV on apoptosis. Abstract The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the study were 28 male Sprague‐Dawley rats (3–4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at 5 mg/kg/day i.p. for a week. Group 3: Administered RSV orally at the dose of 20 mg/kg/day for 30 days by gavage. Group 4: Administered PEMB and RSV at 20 and 5 mg/kg/day RSV, respectively, for 30 days. The results of this study revealed that PEMB leads to a significant increase in thiobarbituric acid reactive substance (TBARS) levels and a significant decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities, and glutathione (GSH) levels in the liver and brain tissues. The decreased SOD, CAT, GPx activities, and GSH levels increased significantly following RSV treatment in Group 4. The PEMB treatment showed histopathological alterations associated with strong positive cysteinyl aspartic acid‐protease‐3 (caspase‐3) immunoreactivity, while RSV treatment reduced both the expression of caspase‐3 protein and the histopathological changes. RSV administration prevents the biochemical, immunological, and histological alterations induced by PEMB. It can be suggested that the lower caspase‐3 immunoreactivity in the PEMB + RSV group than in the PEMB group led to an inhibition of RSV on apoptosis. |
Author | Türkmen, Neşe B. Yüce, Hande Özek, Dilan A. Çiftçi, Osman Taşlıdere, Aslı Ç. Şahin, Yasemin Ünüvar, Songül |
Author_xml | – sequence: 1 givenname: Neşe B. orcidid: 0000-0001-5566-8321 surname: Türkmen fullname: Türkmen, Neşe B. organization: Inonu University – sequence: 2 givenname: Hande orcidid: 0000-0003-2907-2019 surname: Yüce fullname: Yüce, Hande organization: Inonu University – sequence: 3 givenname: Yasemin orcidid: 0000-0003-4226-674X surname: Şahin fullname: Şahin, Yasemin organization: Pamukkale University – sequence: 4 givenname: Aslı Ç. orcidid: 0000-0003-3902-3210 surname: Taşlıdere fullname: Taşlıdere, Aslı Ç. organization: Inonu University – sequence: 5 givenname: Dilan A. orcidid: 0000-0001-9075-4807 surname: Özek fullname: Özek, Dilan A. organization: Firat University – sequence: 6 givenname: Songül orcidid: 0000-0001-8454-490X surname: Ünüvar fullname: Ünüvar, Songül email: songul.unuvar@inonu.edu.tr organization: Inonu University – sequence: 7 givenname: Osman orcidid: 0000-0001-5755-3560 surname: Çiftçi fullname: Çiftçi, Osman organization: Pamukkale University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36419233$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kMtO3DAUhq0KVGDaRV-gstQVi4AvsZMsKeqFCoku6Do6To5bjyb2YDvQYdVH6DP2STAMhRWbc9On70j_AdnxwSMh7zg74oyJ46XJR0IKLV-Rfc66rmK15jsPs6q0btgeOUhpyRhTXaNekz2pa94JKfeJ_x5DxiG7a6RobZlosDRiusYIOYYVhZ_gfMp0jZMpu7udJzD__vx1fpwHHOkvXEMOOfx2g8sbCn6kHuf4fHGeTrBCWnzpDdm1sEr49rEvyI_Pny5Pv1bnF1_OTk_Oq0EqKSsuzGDHUTMDTQ2tbMdBAXS6rpUeGYNSUHcMBDcKWys4WCGYNo3sGmiNlQvyYetdx3A1Y8r9MszRl5e9aFrF21qVPwtyuKWGGFKKaPt1dBPETc9Zf59sX5LtH5It7PtH42wmHJ_I_1EW4HgL3LgVbl429d8-Xm6Vd9vLh7A |
CitedBy_id | crossref_primary_10_3390_nu16132141 |
Cites_doi | 10.1111/apt.15413 10.1093/clinchem/34.3.497 10.1016/S0021-9258(19)52451-6 10.1016/0003-2697(68)90092-4 10.1080/01926230701320337 10.1080/15569527.2017.1361438 10.1093/gastro/goz044 10.1007/s11010-019-03582-z 10.1016/j.neuint.2021.105188 10.1038/nrc.2016.36 10.1080/10408398.2016.1263597 10.1016/S0140-6736(13)62224-2 10.1053/j.semdp.2019.07.009 10.2169/internalmedicine.2591-18 10.1159/000518128 10.1042/BST0351156 10.3390/cancers13184509 10.1172/JCI80011 10.3892/br.2016.777 10.1136/bmj.k793 10.29252/ijrm.16.3.149 10.1111/liv.13746 10.1016/j.ajem.2018.10.040 10.1093/annonc/mdv383 10.1016/j.febslet.2013.10.015 10.1016/j.ejca.2016.02.024 10.1016/S1470-2045(20)30111-X 10.1038/nm0303-269 10.3390/brainsci12060773 10.1016/j.critrevonc.2017.04.011 10.1016/S1470-2045(16)30053-5 10.2174/1567205016666190801153751 10.1007/s00210-018-1495-3 10.1186/s40425-015-0078-9 10.1038/s41523-021-00267-z 10.1186/2051-1426-3-S2-P415 |
ContentType | Journal Article |
Copyright | 2022 Wiley Periodicals LLC. 2023 Wiley Periodicals LLC. |
Copyright_xml | – notice: 2022 Wiley Periodicals LLC. – notice: 2023 Wiley Periodicals LLC. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7U7 8FD C1K FR3 K9. P64 |
DOI | 10.1002/jbt.23263 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Biotechnology Research Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Biotechnology Research Abstracts Technology Research Database Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | Biotechnology Research Abstracts CrossRef MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Public Health Biology |
EISSN | 1099-0461 |
EndPage | n/a |
ExternalDocumentID | 10_1002_jbt_23263 36419233 JBT23263 |
Genre | article Journal Article |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 1L6 1OC 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABOCM ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F3I F5P FEDTE G-S G.N GNP GODZA H.T H.X HF~ HGLYW HHY HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG P2P P2W P2X P4D PQQKQ Q.N Q11 QB0 QRW R.K ROL RWI RX1 RYL SUPJJ SV3 UB1 V2E W8V W99 WBFHL WBKPD WIH WIK WJL WOHZO WQJ WRC WXSBR WYISQ XG1 XPP XV2 ZZTAW ~IA ~WT ACXME CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7U7 8FD C1K FR3 K9. P64 |
ID | FETCH-LOGICAL-c3533-12bcfdd60ba74a838dc5aa964456d00a6d0e690a21b5e8f21af2206b7397a8bf3 |
IEDL.DBID | DR2 |
ISSN | 1095-6670 |
IngestDate | Fri Sep 13 06:04:53 EDT 2024 Fri Aug 23 00:25:54 EDT 2024 Thu May 23 23:32:20 EDT 2024 Sat Aug 24 01:07:08 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | pembrolizumab neurotoxicity resveratrol hepatotoxicity oxidative stress |
Language | English |
License | 2022 Wiley Periodicals LLC. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3533-12bcfdd60ba74a838dc5aa964456d00a6d0e690a21b5e8f21af2206b7397a8bf3 |
ORCID | 0000-0001-9075-4807 0000-0003-3902-3210 0000-0003-2907-2019 0000-0003-4226-674X 0000-0001-8454-490X 0000-0001-5566-8321 0000-0001-5755-3560 |
PMID | 36419233 |
PQID | 2785184553 |
PQPubID | 1006378 |
PageCount | 10 |
ParticipantIDs | proquest_journals_2785184553 crossref_primary_10_1002_jbt_23263 pubmed_primary_36419233 wiley_primary_10_1002_jbt_23263_JBT23263 |
PublicationCentury | 2000 |
PublicationDate | March 2023 2023-Mar 2023-03-00 20230301 |
PublicationDateYYYYMMDD | 2023-03-01 |
PublicationDate_xml | – month: 03 year: 2023 text: March 2023 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Hoboken |
PublicationTitle | Journal of biochemical and molecular toxicology |
PublicationTitleAlternate | J Biochem Mol Toxicol |
PublicationYear | 2023 |
Publisher | Wiley Subscription Services, Inc |
Publisher_xml | – name: Wiley Subscription Services, Inc |
References | 1968; 25 2019; 8 2021; 7 2018; 360 2015; 3 2019; 50 2015; 125 2019; 37 2019; 58 2019; 36 2019; 16 1988; 34 2019; 460 2016; 17 2016; 16 2017; 115 2007; 35 2016; 5 2021; 13 2015; 26 1967; 70 2021; 15 2018; 391 2016; 2 2013; 12 2003; 9 1998; 108 1951; 193 2022; 12 2021; 150 1984 2016; 60 2020; 21 2014; 383 2018; 16 2018; 38 2018; 37 2014; 588 2018; 58 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_33_1 Paglia D. E. (e_1_2_9_21_1) 1967; 70 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_14_1 e_1_2_9_39_1 Valsan A. (e_1_2_9_12_1) 2016; 2 e_1_2_9_36_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_18_1 e_1_2_9_42_1 e_1_2_9_20_1 e_1_2_9_40_1 e_1_2_9_22_1 Mokni M. (e_1_2_9_41_1) 2013; 12 Yagi K. (e_1_2_9_17_1) 1998; 108 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 Aebi H. (e_1_2_9_19_1) 1984 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
References_xml | – volume: 9 issue: 3 year: 2003 publication-title: Nat. Med. – volume: 108 start-page: 101 year: 1998 publication-title: Methods Mol. Biol. – volume: 17 start-page: 976 year: 2016 publication-title: Lancet Oncol. – volume: 37 start-page: 376.e1 issue: 376 year: 2019 publication-title: Am. J. Emerg. Med. – volume: 13 issue: 18 year: 2021 publication-title: Cancers – volume: 26 start-page: 2375 year: 2015 publication-title: Ann. Oncol. – volume: 7 start-page: 59 year: 2021 publication-title: NPJ Breast Cancer – volume: 25 start-page: 192 issue: 1 year: 1968 publication-title: Anal. Biochem. – volume: 588 start-page: 368 year: 2014 publication-title: FEBS Lett. – volume: 150 year: 2021 publication-title: Neurochem. Int. – volume: 35 start-page: 495 year: 2007 publication-title: Toxicol. Pathol. – volume: 460 start-page: 217 year: 2019 publication-title: Mol. Cell. Biochem. – volume: 34 issue: 3 year: 1988 publication-title: Clin. Chem. – volume: 70 start-page: 158 issue: 1 year: 1967 publication-title: J. Lab. Clin. Med. – volume: 37 start-page: 151 year: 2018 publication-title: Cutaneous Ocul. Toxicol. – volume: 58 start-page: 1428 year: 2018 publication-title: Crit. Rev. Food Sci. Nutr. – volume: 193 start-page: 265 year: 1951 publication-title: J. Biol. Chem. – volume: 21 start-page: 655 year: 2020 publication-title: Lancet Oncol. – volume: 2 start-page: 75 year: 2016 publication-title: South Ind. J. Biol. Sci. – volume: 3 start-page: 36 year: 2015 publication-title: J. Immunother. Cancer – volume: 16 year: 2018 publication-title: Int. J. Reprod. Biomed. – volume: 391 start-page: 783 year: 2018 publication-title: Naunyn‐Schmiedeberg's Arch. Pharmacol. – volume: 38 start-page: 976 year: 2018 publication-title: Liver Int. – volume: 50 start-page: 800 year: 2019 publication-title: Aliment. Pharmacol. Ther. – volume: 360 year: 2018 publication-title: BMJ – volume: 8 start-page: 50 year: 2019 publication-title: Gastroenterol. Rep. – volume: 35 year: 2007 publication-title: Biochem. Soc. Trans. – volume: 115 start-page: 50 year: 2017 publication-title: Crit. Rev. Oncol. Hematol. – volume: 3 issue: 2 year: 2015 publication-title: J. Immunother. Cancer – volume: 58 start-page: 3283 year: 2019 publication-title: Intern. Med. – volume: 16 start-page: 710 year: 2019 publication-title: Curr. Alzheimer Res. – volume: 125 start-page: 3384 year: 2015 publication-title: J. Clin. Invest. – start-page: 121 year: 1984 – volume: 60 start-page: 210 year: 2016 publication-title: Eur. J. Cancer – volume: 383 start-page: 549 year: 2014 publication-title: Lancet – volume: 12 issue: 6 year: 2022 publication-title: Brain Sci. – volume: 5 start-page: 525 year: 2016 publication-title: Biomed. Rep. – volume: 12 start-page: 867 year: 2013 publication-title: Iran. J. Pharm. Res. – volume: 36 start-page: 434 issue: 6 year: 2019 publication-title: Semin. Diagn. Pathol. – volume: 15 start-page: 742 issue: 2 year: 2021 publication-title: Case Rep. Gastroenterol. – volume: 16 start-page: 275 year: 2016 publication-title: Nat. Rev. Cancer – volume: 2 start-page: 75 year: 2016 ident: e_1_2_9_12_1 publication-title: South Ind. J. Biol. Sci. contributor: fullname: Valsan A. – ident: e_1_2_9_29_1 doi: 10.1111/apt.15413 – ident: e_1_2_9_18_1 doi: 10.1093/clinchem/34.3.497 – ident: e_1_2_9_22_1 doi: 10.1016/S0021-9258(19)52451-6 – ident: e_1_2_9_20_1 doi: 10.1016/0003-2697(68)90092-4 – ident: e_1_2_9_38_1 doi: 10.1080/01926230701320337 – ident: e_1_2_9_24_1 doi: 10.1080/15569527.2017.1361438 – ident: e_1_2_9_30_1 doi: 10.1093/gastro/goz044 – ident: e_1_2_9_16_1 doi: 10.1007/s11010-019-03582-z – ident: e_1_2_9_14_1 doi: 10.1016/j.neuint.2021.105188 – ident: e_1_2_9_25_1 doi: 10.1038/nrc.2016.36 – ident: e_1_2_9_40_1 doi: 10.1080/10408398.2016.1263597 – ident: e_1_2_9_2_1 doi: 10.1016/S0140-6736(13)62224-2 – ident: e_1_2_9_32_1 doi: 10.1053/j.semdp.2019.07.009 – ident: e_1_2_9_31_1 doi: 10.2169/internalmedicine.2591-18 – ident: e_1_2_9_33_1 doi: 10.1159/000518128 – ident: e_1_2_9_11_1 doi: 10.1042/BST0351156 – volume: 70 start-page: 158 issue: 1 year: 1967 ident: e_1_2_9_21_1 publication-title: J. Lab. Clin. Med. contributor: fullname: Paglia D. E. – ident: e_1_2_9_42_1 doi: 10.3390/cancers13184509 – ident: e_1_2_9_3_1 doi: 10.1172/JCI80011 – ident: e_1_2_9_10_1 doi: 10.3892/br.2016.777 – ident: e_1_2_9_7_1 doi: 10.1136/bmj.k793 – ident: e_1_2_9_15_1 doi: 10.29252/ijrm.16.3.149 – ident: e_1_2_9_28_1 doi: 10.1111/liv.13746 – ident: e_1_2_9_9_1 doi: 10.1016/j.ajem.2018.10.040 – ident: e_1_2_9_8_1 doi: 10.1093/annonc/mdv383 – ident: e_1_2_9_26_1 doi: 10.1016/j.febslet.2013.10.015 – ident: e_1_2_9_36_1 doi: 10.1016/j.ejca.2016.02.024 – ident: e_1_2_9_34_1 doi: 10.1016/S1470-2045(20)30111-X – volume: 12 start-page: 867 year: 2013 ident: e_1_2_9_41_1 publication-title: Iran. J. Pharm. Res. contributor: fullname: Mokni M. – ident: e_1_2_9_5_1 doi: 10.1038/nm0303-269 – ident: e_1_2_9_37_1 doi: 10.3390/brainsci12060773 – start-page: 121 volume-title: Methods in Enzymology year: 1984 ident: e_1_2_9_19_1 contributor: fullname: Aebi H. – ident: e_1_2_9_6_1 doi: 10.1016/j.critrevonc.2017.04.011 – ident: e_1_2_9_35_1 doi: 10.1016/S1470-2045(16)30053-5 – ident: e_1_2_9_13_1 doi: 10.2174/1567205016666190801153751 – ident: e_1_2_9_23_1 doi: 10.1007/s00210-018-1495-3 – volume: 108 start-page: 101 year: 1998 ident: e_1_2_9_17_1 publication-title: Methods Mol. Biol. contributor: fullname: Yagi K. – ident: e_1_2_9_27_1 doi: 10.1186/s40425-015-0078-9 – ident: e_1_2_9_39_1 doi: 10.1038/s41523-021-00267-z – ident: e_1_2_9_4_1 doi: 10.1186/2051-1426-3-S2-P415 |
SSID | ssj0005975 |
Score | 2.3692524 |
Snippet | The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for the... The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)-induced toxicity. Obtained for the... Abstract The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity.... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | e23263 |
SubjectTerms | Animal tissues Animals Antioxidants - pharmacology Apoptosis Aspartic acid Brain Caspase Caspase 3 - metabolism Catalase Catalase - metabolism Chemical and Drug Induced Liver Injury - metabolism Glutathione Glutathione - metabolism Glutathione peroxidase Glutathione Peroxidase - metabolism Hepatotoxicity Immunology Immunoreactivity Liver Liver - metabolism Male Males Neurotoxicity Oxidative Stress Pembrolizumab Peroxidase Rats Rats, Sprague-Dawley Resveratrol Resveratrol - pharmacology Superoxide dismutase Superoxide Dismutase - metabolism Thiobarbituric acid Toxicity |
Title | Protective effect of resveratrol against pembrolizumab‐induced hepatotoxicity and neurotoxicity in male rats |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbt.23263 https://www.ncbi.nlm.nih.gov/pubmed/36419233 https://www.proquest.com/docview/2785184553/abstract/ |
Volume | 37 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3datswFMdFKBQKpV2zdW3XDTF6sRuntmwpCrvaRkMotIySQC8G5ujDW9bGDolTtl71EfaMe5IdWbFDVgajN8ZYtrB9JJ2fvv6HkBOpexz9vA0MSB4kFkSgDISBRl_MElDYKLoZ3YtLMRgl59f8ukXe13thvD5EM-DmakbVXrsKDmp-uhIN_a7KDuKAcEqfTkjPAdHVSjoKQZlXM509HgjRDWtVoZCdNk-u-6JHgLnOq5XD6e-SL_Wr-nUmN51FqTr6_i8Vxyd-yzOyswRR-sGXnD3SsnmbbPrQlD_bZNuP51G_Tek5yT97QQdsHKlfA0KLjGJf_c6pMs-KWwpfYYysSad2olwooPvFBNTvh1_Y6cfiY-g3dHxlURY_xhrJn0JuaCWm2VwZ53SC7opifvMXZNQ_G34aBMtYDWhVJMYgYkpnxohQQTcBGUujOUAPaYsLE4aAB4sdcWCR4lZmLIKMsVCoLvIQSJXF-2QjL3J7QKiOJLYMoVYa0UNzqWQCYCG2wGSUmeiQvK2tlk69JEfqxZdZij8yrX7kITmu7Zkua-U8ZV3kS5lwjskvvY2bHGLh5sNjTHlXWerfWafnH4fVydH_3_qKbLk49X7x2jHZKGcL-xppplRvqmL7B6hf8p4 |
link.rule.ids | 315,786,790,1382,27957,27958,46329,46753 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB61RahIiEfpi7ZgIQ5csps4sdcrcaGIailthdBW6gVF40faBTap2iyCnvoT-hv5JUzszVYtQkJcoihOLMfjmfnGj28AXirTF-TnXWRRiShzKCNtMY4M-WKeoSaj2Kzo7h_IwWG2eySO5uB1exYm8EPMJtwazfD2ulHwZkK6e80a-kXXHcIDMp2HO6TuwgdUn67JowgqC7_W2ReRlL245RWKeXf26U1v9AfEvIlYvcvZeQif28aGnSZfO5Nad8zFLR7H__2bR_BgikXZmzB4HsOcK5fgbshO-XMJ7ocpPRZOKj2B8mPgdCD7yMI2EFYVjML17w0x81n1jeExjghuslM31k02oIvJGPWvyyuK-2kEWXZCvq-u6urHyBD4Z1ha5vk0Z09GJRuTx2JU3_kyHO68G74dRNN0DSRYAo1RwrUprJWxxl6GKlXWCMQ-AS4hbRwjXRzF4sgTLZwqeIIF57HUPYJEqHSRrsBCWZVuDZhJFBmH2GhD6MMIpVWG6DB1yFVS2GQdXrRiy08DK0ce-Jd5Th2Z-45ch81WoPlUMc9z3iOIqTIhqHg1CHlWQyqbJfGUSl55Uf296nx3e-hvnv77q89hcTDc38v33h982IB7Tdr6sJdtExbqs4nbInBT62d-DP8G2C_2wA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS9xAEB_UUhGKtdZarW0X6UNfciab7N4ePrW1h9-IKPhQCLMfqdd6yaE5UZ_8E_wb-5d0kr2caCmUvoSQTZbNzuzMb_bjNwAflOkI8vMusKhEkDiUgbYYBoZ8MU9Qk1GsVnT39uXmcbJ9Ik4mYL05C-P5IcYTbtXIqO11NcAHNlu7Jw39ocsWwQEZT8KTRMa8UumNw3vuKELKol7q7IhAynbY0AqFfG386UNn9AfCfAhYa4_TfQ7fmrb6jSY_W8NSt8zNIxrH__yZOZgdIVH2yavOC5hw-Tw89bkpr-fhmZ_QY_6c0kvIDzyjA1lH5jeBsCJjFKxfVrTM58UZw-_YI7DJBq6vq1xAN8M-6l-3dxT1k_5YdkqeryzK4qpnCPozzC2r2TTHT3o565O_YlTfxQIcd78efdkMRskaSKwEGYOIa5NZK0ON7QRVrKwRiB2CW0LaMES6OIrEkUdaOJXxCDPOQ6nbBIhQ6Sx-BVN5kbvXwEykyDSERhvCHkYorRJEh7FDrqLMRkuw2kgtHXhOjtSzL_OUOjKtO3IJVhp5pqNheZHyNgFMlQhBxYtexuMaYlktiMdU8rGW1N-rTrc_H9U3y__-6nuYPtjoprtb-ztvYKbKWe83sq3AVHk-dG8J2ZT6Xa3BvwEI3vVv |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protective+effect+of+resveratrol+against+pembrolizumab%E2%80%90induced+hepatotoxicity+and+neurotoxicity+in+male+rats&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.au=T%C3%BCrkmen%2C+Ne%C5%9Fe+B&rft.au=Y%C3%BCce%2C+Hande&rft.au=%C5%9Eahin%2C+Yasemin&rft.au=Ta%C5%9Fl%C4%B1dere%2C+Asl%C4%B1+%C3%87&rft.date=2023-03-01&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=1095-6670&rft.eissn=1099-0461&rft.volume=37&rft.issue=3&rft_id=info:doi/10.1002%2Fjbt.23263&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1095-6670&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1095-6670&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1095-6670&client=summon |