Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations
Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [18F]‐fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 co...
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| Published in | Annals of neurology Vol. 87; no. 4; pp. 652 - 657 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.04.2020
Wiley Subscription Services, Inc |
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| ISSN | 0364-5134 1531-8249 1531-8249 |
| DOI | 10.1002/ana.25692 |
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| Abstract | Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [18F]‐fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [18F]‐fluorodopa uptake (Ki). Forty‐eight subjects were followed longitudinally. Cross‐sectional and longitudinal comparisons of Ki and Ki change found significant effects of Parkinson disease. However, at baseline and over time, striatal [18F]‐fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652–657 |
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| AbstractList | Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [18F]‐fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [18F]‐fluorodopa uptake (Ki). Forty‐eight subjects were followed longitudinally. Cross‐sectional and longitudinal comparisons of Ki and Ki change found significant effects of Parkinson disease. However, at baseline and over time, striatal [18F]‐fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652–657 Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [18 F]-fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [18 F]-fluorodopa uptake (Ki ). Forty-eight subjects were followed longitudinally. Cross-sectional and longitudinal comparisons of Ki and Ki change found significant effects of Parkinson disease. However, at baseline and over time, striatal [18 F]-fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652-657.Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [18 F]-fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [18 F]-fluorodopa uptake (Ki ). Forty-eight subjects were followed longitudinally. Cross-sectional and longitudinal comparisons of Ki and Ki change found significant effects of Parkinson disease. However, at baseline and over time, striatal [18 F]-fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652-657. Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [ F]-fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [ F]-fluorodopa uptake (K ). Forty-eight subjects were followed longitudinally. Cross-sectional and longitudinal comparisons of K and K change found significant effects of Parkinson disease. However, at baseline and over time, striatal [ F]-fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652-657. Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [ 18 F]‐fluorodopa positron emission tomography studies of 57 homozygous and heterozygous GBA1 mutation carriers (15 with parkinsonism) and 98 controls looking for early indications of dopamine loss using voxelwise analyses to identify group differences in striatal [ 18 F]‐fluorodopa uptake (K i ). Forty‐eight subjects were followed longitudinally. Cross‐sectional and longitudinal comparisons of K i and K i change found significant effects of Parkinson disease. However, at baseline and over time, striatal [ 18 F]‐fluorodopa uptake in mutation carriers without parkinsonism did not significantly differ from controls. ANN NEUROL 2020;87:652–657 |
| Author | Groden, Catherine Ianni, Angela M. Sidransky, Ellen Berman, Karen F. Masdeu, Joseph C. Gregory, Michael D. Grogans, Shannon E. Lopez, Grisel Kim, Jenny Eisenberg, Daniel P. |
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| Cites_doi | 10.1016/j.expneurol.2009.12.021 10.1038/jcbfm.1985.87 10.1212/NXG.0000000000000104 10.1002/ana.410360512 10.1001/jamaneurol.2014.2950 10.1016/S1474-4422(11)70214-9 10.1093/brain/aws174 10.1038/jcbfm.1993.8 10.1001/jamaneurol.2013.1925 10.1159/000447510 10.1097/WCO.0000000000000715 10.1136/jnnp.55.3.181 10.1056/NEJMoa0901281 10.1136/jnnp-2019-320394 10.1034/j.1399-0004.2002.610106.x 10.1016/j.parkreldis.2018.10.025 |
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| References | 1993; 13 2019; 90 2016; 2 2012; 135 1985; 5 2002; 61 2015; 72 2019; 32 2010; 222 2019; 59 2016; 76 1994; 36 2013; 70 2011; 10 2009; 361 1992; 55 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_13_1 e_1_2_8_14_1 e_1_2_8_15_1 e_1_2_8_16_1 Lopez G (e_1_2_8_8_1) e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_10_1 e_1_2_8_11_1 e_1_2_8_12_1 |
| References_xml | – volume: 5 start-page: 584 year: 1985 end-page: 590 article-title: Graphical evaluation of blood‐to‐brain transfer constants from multiple‐time uptake data publication-title: J Cereb Blood Flow Metab – volume: 59 start-page: 32 year: 2019 end-page: 38 article-title: New era in disease modification in Parkinson's disease: review of genetically targeted therapeutics publication-title: Parkinsonism Relat Disord – article-title: Clinical Evaluation of Sibling Pairs With Gaucher Disease Discordant for Parkinsonism publication-title: Mov Disord – volume: 10 start-page: 987 year: 2011 end-page: 1001 article-title: Advances in imaging in Parkinson's disease publication-title: Lancet Neurol – volume: 72 start-page: 201 year: 2015 end-page: 208 article-title: Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation‐positive cohort publication-title: JAMA Neurol – volume: 76 start-page: 19 year: 2016 end-page: 21 article-title: Prodromal clinical markers of Parkinson disease in Gaucher disease individuals publication-title: Eur Neurol – volume: 32 start-page: 589 year: 2019 end-page: 596 article-title: GBA1‐associated parkinsonism: new insights and therapeutic opportunities publication-title: Curr Opin Neurol – volume: 13 start-page: 57 year: 1993 end-page: 69 article-title: 6‐[18F]fluoro‐L‐dopa metabolism in living human brain: a comparison of six analytical methods publication-title: J Cereb Blood Flow Metab – volume: 36 start-page: 759 year: 1994 end-page: 764 article-title: Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic parkinsonism publication-title: Ann Neurol – volume: 61 start-page: 32 year: 2002 end-page: 34 article-title: The E326K mutation and Gaucher disease: mutation or polymorphism? publication-title: Clin Genet – volume: 2 year: 2016 article-title: GBA p.T369M substitution in Parkinson disease: polymorphism or association? A meta‐analysis publication-title: Neurol Genet – volume: 90 start-page: 1091 year: 2019 end-page: 1097 article-title: Evolution of prodromal parkinsonian features in a cohort of GBA mutation‐positive individuals: a 6‐year longitudinal study publication-title: J Neurol Neurosurg Psychiatry – volume: 70 start-page: 727 year: 2013 end-page: 735 article-title: A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies publication-title: JAMA Neurol – volume: 222 start-page: 120 year: 2010 end-page: 124 article-title: In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study publication-title: Exp Neurol – volume: 135 start-page: 2440 issue: pt 8 year: 2012 end-page: 2448 article-title: The neurobiology of glucocerebrosidase‐associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow publication-title: Brain – volume: 55 start-page: 181 year: 1992 end-page: 184 article-title: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico‐pathological study of 100 cases publication-title: J Neurol Neurosurg Psychiatry – volume: 361 start-page: 1651 year: 2009 end-page: 1661 article-title: Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease publication-title: N Engl J Med – ident: e_1_2_8_13_1 doi: 10.1016/j.expneurol.2009.12.021 – ident: e_1_2_8_8_1 article-title: Clinical Evaluation of Sibling Pairs With Gaucher Disease Discordant for Parkinsonism publication-title: Mov Disord – ident: e_1_2_8_9_1 doi: 10.1038/jcbfm.1985.87 – ident: e_1_2_8_7_1 doi: 10.1212/NXG.0000000000000104 – ident: e_1_2_8_12_1 doi: 10.1002/ana.410360512 – ident: e_1_2_8_14_1 doi: 10.1001/jamaneurol.2014.2950 – ident: e_1_2_8_11_1 doi: 10.1016/S1474-4422(11)70214-9 – ident: e_1_2_8_4_1 doi: 10.1093/brain/aws174 – ident: e_1_2_8_10_1 doi: 10.1038/jcbfm.1993.8 – ident: e_1_2_8_3_1 doi: 10.1001/jamaneurol.2013.1925 – ident: e_1_2_8_16_1 doi: 10.1159/000447510 – ident: e_1_2_8_18_1 doi: 10.1097/WCO.0000000000000715 – ident: e_1_2_8_5_1 doi: 10.1136/jnnp.55.3.181 – ident: e_1_2_8_2_1 doi: 10.1056/NEJMoa0901281 – ident: e_1_2_8_15_1 doi: 10.1136/jnnp-2019-320394 – ident: e_1_2_8_6_1 doi: 10.1034/j.1399-0004.2002.610106.x – ident: e_1_2_8_17_1 doi: 10.1016/j.parkreldis.2018.10.025 |
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| Snippet | Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed... Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [... Mutations in GBA1, the gene mutated in Gaucher disease, are a common genetic risk factor for Parkinson disease, although the penetrance is low. We performed [... |
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| SubjectTerms | Dopamine Emission analysis Gaucher's disease Health risks Movement disorders Mutation Neostriatum Neurodegenerative diseases Parkinson's disease Positron emission Positron emission tomography Risk analysis Risk factors Tomography |
| Title | Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations |
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