Attenuation of aquaporin‐3 and epidermal growth factor receptor expression and activation in systemic sclerosis dermal fibroblasts

• Published in: Journal of cellular physiology Vol. 234; no. 8; pp. 12876 - 12883
• Main Authors: Farhadi, Elham, Mahmoudi, Mahdi, Rahmani, Farzaneh, Yousefi, Bahman, Sarafnejad, Abdolfattah, Kavosi, Hoda, Karimizadeh, Elham, Jamshidi, Ahmadreza, Gharibdoost, Farhad
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2019
• Subjects: Activation; Adult; Aquaporin 3; Aquaporin 3 - genetics; Aquaporin 3 - metabolism; Aquaporins; Attenuation; Cells, Cultured; Dehydration; Epidermal growth factor; Epidermal Growth Factor - metabolism; epidermal growth factor receptor; Epidermal growth factor receptors; ErbB Receptors - metabolism; Female; Fibroblasts; Fibroblasts - metabolism; Gene expression; Growth factors; Humans; Male; Matrix metalloproteinase; Metalloproteinase; Middle Aged; mRNA; Patients; Polymerase chain reaction; Proteins; Scleroderma; Scleroderma, Systemic - metabolism; Signal Transduction - drug effects; Skin; skin fibroblast; Systemic sclerosis; Tissue inhibitor of metalloproteinase 1; Transforming growth factor; Transforming growth factor-b1; Wound healing; skin fibroblast; aquaporin-3; epidermal growth factor receptor; scleroderma

Objectives Impaired wound healing and skin dehydration are the mainstay of systemic sclerosis (SSc) cutaneous manifestations. Aquaporin‐3 (AQP3) has a pivotal role in skin hydration and wound healing. Epidermal growth factor receptor (EGFR) activation is impaired in SSc fibroblasts. It is unclear wh...