Nerve‐tumour interaction enhances the aggressiveness of oral squamous cell carcinoma

• Published in: Clinical otolaryngology Vol. 44; no. 6; pp. 1087 - 1095
• Main Authors: Lee, Tsung‐Lun, Chiu, Po‐Hsien, Li, Wing‐Yin, Yang, Muh‐Hwa, Wei, Pei‐Yin, Chu, Pen‐Yuan, Wang, Yi‐Fen, Tai, Shyh‐Kuan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2019
• Subjects: Cell migration; Drug dosages; Health care facilities; Human performance; Implantation; In vivo methods and tests; Lymph nodes; Lymphatic system; Metastases; Metastasis; nerve‐tumour interaction; Nervous system; Oral cancer; Oral squamous cell carcinoma; paracrine; Paracrine signalling; Pathogenesis; perineural invasion; perineural invasion focus number; Peripheral nerves; Soft tissues; Squamous cell carcinoma; Surgical implants; Therapeutic targets; Tumors; perineural invasion; oral squamous cell carcinoma; nerve-tumour interaction; paracrine; perineural invasion focus number

Objectives Perineural invasion (PNI) is a poor prognostic pathologic feature of oral squamous cell carcinoma (OSCC). The mechanisms of PNI remain poorly understood, and nerve‐tumour interactions have been implicated for its pathogenesis. Design and setting Systematic investigation of nerve‐tumour in...