In Healthy Adults, Biological Activity of Vitamin D, as Assessed by Serum PTH, Is Largely Independent of DBP Concentrations

• Published in: Journal of bone and mineral research Vol. 29; no. 2; pp. 494 - 499
• Main Authors: Dastani, Zari, Berger, Claudie, Langsetmo, Lisa, Fu, Lei, Wong, Betty YL, Malik, Suneil, Goltzman, David, Cole, David E, Richards, J Brent
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2014
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Female; Humans; Male; Middle Aged; Parathyroid Hormone - blood; PTH; Vitamin D - analogs & derivatives; Vitamin D - blood; VITAMIN D BINDING PROTEIN (DBP); VITAMIN D CONCENTRATION; Vitamin D-Binding Protein - blood; PTH; VITAMIN D BINDING PROTEIN (DBP); VITAMIN D CONCENTRATION

ABSTRACT Vitamin D insufficiency, as measured by 25‐hydroxyvitamin D (25[OH]D) levels, has been associated with important health outcomes. The majority of vitamin D in circulation is bound to vitamin D–binding protein (DBP) and albumin, and recent genetic studies have demonstrated that serum DBP is...