Sequential class switch recombination to IgE and allergen‐induced accumulation of IgE+ plasmablasts occur in the nasal mucosa of local allergic rhinitis patients

• Published in: Allergy (Copenhagen) Vol. 77; no. 9; pp. 2712 - 2724
• Main Authors: Testera‐Montes, Almudena, Palomares, Francisca, Jurado‐Escobar, Raquel, Fernandez‐Santamaria, Ruben, Ariza, Adriana, Verge, Jesus, Salas, Maria, Campo, Paloma, Mayorga, Cristobalina, Torres, Maria Jose, Rondon, Carmen, Eguiluz‐Gracia, Ibon
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.09.2022
• Subjects: Allergens; Allergic rhinitis; Allergies; Antigens, Dermatophagoides; Atopy; basophil activation test; Biopsy; CD19 antigen; CD20 antigen; CD38 antigen; class switch recombination; Class switching; CXCR3 protein; Dermatophagoides pteronyssinus; Flow cytometry; Gene expression; Hay fever; Humans; IgE; Immunoglobulin E; Immunoglobulin G; Immunohistochemistry; local allergic rhinitis; Lymphocytes; Mucosa; Nasal Mucosa; Nasal Provocation Tests; plasma cell; plasmablast; Recombination; Rhinitis; Rhinitis, Allergic - diagnosis; basophil activation test; plasmablast; class switch recombination; plasma cell; IgE; local allergic rhinitis

Background The involvement of allergen‐specific (s)IgE in local allergic rhinitis (LAR) has been debated. Here, we investigate the effect of nasal allergen challenge with Dermatophagoides pteronyssinus (NAC‐DP) in mucosal and peripheral B‐cell subpopulations in LAR patients. Methods Nine LAR, 5 alle...