Long noncoding RNA APTR contributes to osteosarcoma progression through repression of miR‐132‐3p and upregulation of yes‐associated protein 1

• Published in: Journal of cellular physiology Vol. 234; no. 6; pp. 8998 - 9007
• Main Authors: Guan, Hongya, Shang, Guowei, Cui, Yuanbo, Liu, Jiu, Sun, Xiaoya, Cao, Wei, Wang, Yisheng, Li, Yuebai
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2019
• Subjects: 3' Untranslated Regions; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adolescent; Alu‐mediated p21 transcriptional regulator (APTR); Apoptosis; Binding Sites; Biocompatibility; Bone cancer; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Female; Gelatinase B; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Kinases; long noncoding RNAs (lncRNA); Male; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miR‐132‐3p; Molecular modelling; Neoplasm Invasiveness; Osteosarcoma; osteosarcoma (OS); Osteosarcoma - genetics; Osteosarcoma - metabolism; Osteosarcoma - pathology; progression; Proteins; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Regulatory mechanisms (biology); Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Sarcoma; Signal Transduction; Transcription; Transcription Factors - genetics; Transcription Factors - metabolism; Up-regulation; Yap1 protein; Yes-associated protein; Yes‐associated protein 1 (YAP1); Yes-associated protein 1 (YAP1); progression; miR-132-3p; Alu-mediated p21 transcriptional regulator (APTR); osteosarcoma (OS); long noncoding RNAs (lncRNA)

A growing amount of evidence has shown that long noncoding RNAs (lncRNAs) play crucial roles in osteosarcoma (OS). However, little knowledge is available about the functional roles and molecular mechanisms of lncRNA Alu‐mediated p21 transcriptional regulator (APTR) in OS. Herein, APTR expression was...