Increasing acetyl‐CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

• Published in: Journal of neurochemistry Vol. 141; no. 5; pp. 721 - 737
• Main Authors: Chevalier, Amber C., Rosenberger, Thad A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2017
• Subjects: acetate; Acetates - therapeutic use; Acetic acid; Acetyl Coenzyme A - metabolism; Acetylation; acetyl‐CoA; Animal models; Animals; Behavior, Animal - drug effects; Borreliosis; Brain; Cholesterol; Choline; Chromatography, Thin Layer; Dietary supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental - chemically induced; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Encephalomyelitis, Autoimmune, Experimental - prevention & control; Energy reserves; Esters; Ethanolamine; Experimental allergic encephalomyelitis; fatty acid; Fatty acids; Fatty Acids - metabolism; Female; Glycoproteins; Histochemistry; Histones; Inflammation; lipid; Lipid metabolism; Lipid Metabolism - drug effects; Lipid Metabolism - physiology; Lipids; Metabolism; Mice; Mice, Inbred C57BL; Multiple sclerosis; Myelin; Myelin Sheath - metabolism; Myelin-Oligodendrocyte Glycoprotein - toxicity; myelination; Neurochemistry; Neuroprotection; Oligodendrocyte-myelin glycoprotein; Peptide Fragments - toxicity; Phosphatidylserine; Phospholipase; Phospholipase A2; Phospholipases A2 - metabolism; Protein turnover; Rodents; Spinal cord; Spinal Cord - drug effects; Spinal Cord - enzymology; Spinal cord injuries; Statistics, Nonparametric; Triglycerides - pharmacology; acetate; phospholipase; fatty acid; myelination; acetyl-CoA; lipid

Acetate supplementation increases brain acetyl‐CoA metabolism, alters histone and non‐histone protein acetylation, increases brain energy reserves, and is anti‐inflammatory and neuroprotective in rat models of neuroinflammation and neuroborreliosis. To determine the impact acetate supplementation ha...