Prospective study evaluating immune‐mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints

• Published in: Neurogastroenterology and motility Vol. 31; no. 4; pp. e13542 - n/a
• Main Authors: Florens, Morgane V., Van Wanrooy, Sander, Dooley, James, Aguilera‐Lizarraga, Javier, Vanbrabant, Winde, Wouters, Mira M., Van Oudenhove, Lukas, Peetermans, Willy E., Liston, Adrian, Boeckxstaens, Guy E.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2019
• Subjects: Abdomen; Abdominal Pain - complications; Adult; Anxiety; Anxiety - complications; Diarrhea; Diarrhea - complications; Female; Gastroenteritis; Gastroenteritis - complications; Gene expression; Humans; Immunoglobulin E; Infections; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - etiology; Lymphocytes B; Male; Middle Aged; Pain; Peripheral blood mononuclear cells; Prospective Studies; Rectum; Risk Factors; Surveys and Questionnaires; Travel

Background The role of persistent immune activation in postinfectious irritable bowel syndrome (PI‐IBS) remains controversial. Here, we prospectively studied healthy subjects traveling to destinations with a high‐risk to develop infectious gastroenteritis (IGE) in order to identify immune‐mediated m...