Extracellular vesicles from early stage Plasmodium falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

• Published in: Cellular microbiology Vol. 20; no. 5; pp. e12822 - n/a
• Main Authors: Sampaio, Natália G., Emery, Samantha J., Garnham, Alexandra L., Tan, Qiao Y., Sisquella, Xavier, Pimentel, Matthew A., Jex, Aaron R., Regev‐Rudzki, Neta, Schofield, Louis, Eriksson, Emily M.
• Format: Journal Article
• Language: English
• Published: England Hindawi Limited 01.05.2018
• Subjects: Animals; Cell Adhesion - genetics; Cell Communication - genetics; Cell interactions; Cell permeability; Cellular stress response; Cytokines; diseases; Drug resistance; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Erythrocytes; Erythrocytes - parasitology; Extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Gene expression; Host-Parasite Interactions - genetics; Humans; immunology; Immunostimulation; infection; Inflammation; Malaria; Malaria, Falciparum - blood; Malaria, Falciparum - genetics; Malaria, Falciparum - parasitology; Monocytes; Monocytes - metabolism; Monocytes - parasitology; Parasites; Pathogenesis; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - pathogenicity; Proteins; Proteomics; Protozoan Proteins - genetics; Transcription; transcriptomics; Vector-borne diseases; Vesicles; Virulence; Virulence factors; transcriptomics; diseases; infection; extracellular vesicles; proteomics; immunology

Pathogens can release extracellular vesicles (EVs) for cell–cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are immunostimulatory...