Ochratoxin a induces hepatic fibrosis through TGF‐β receptor I/Smad2/3 signaling pathway

• Published in: Environmental toxicology Vol. 37; no. 8; pp. 2084 - 2095
• Main Authors: Chae, Seung A, Pyo, Min Cheol, Yoo, Hee Joon, Lee, Kwang‐Won
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2022; Wiley Subscription Services, Inc
• Subjects: Actin; Alanine; Alanine transaminase; Alkaline phosphatase; Aspartate aminotransferase; Bilirubin; Cell membranes; Cereals; Damage assessment; Fibronectin; Fibrosis; Fungi; Gene expression; Hepatocytes; Kinases; Liver; liver fibrosis; Markers; Mesenchyme; mRNA; Muscles; Mycotoxins; Ochratoxin A; Phosphatase; Protein expression; Proteins; Receptors; Signal transduction; Signaling; siRNA; Smad2; Smad2 protein; Smad3; Smad3 protein; Smooth muscle; TGF‐β receptor I; Transaminase; Transforming growth factor-b; Smad2; Smad3; liver fibrosis; Ochratoxin A; TGF-β receptor I

Ochratoxin A (OTA) is a mycotoxin generated by Penicillium and Aspergillus species. It is often found in cereals. We hypothesized that OTA exposure induces epithelial–mesenchymal transition (EMT), leading to liver fibrosis. In this research, we explored whether the TGF‐β receptor I (TGF‐β RI)/Smad2/...