Non‐water‐excitation MR spectroscopy techniques to explore exchanging protons in human brain at 3 T

• Published in: Magnetic resonance in medicine Vol. 84; no. 5; pp. 2352 - 2363
• Main Authors: Dziadosz, Martyna, Bogner, Wolfgang, Kreis, Roland
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2020
• Subjects: Adiabatic; Adiabatic flow; amides; brain; Brain - diagnostic imaging; Cycles; downfield; Exchanging; Excitation; Excitation spectra; Frequency ranges; human; Humans; In vivo methods and tests; Localization; Magnetic Resonance Spectroscopy; magnetization exchange; Metabolites; Phantoms, Imaging; proton MR spectroscopy; Protons; Saturation; Scanners; Spectroscopy; Spectrum analysis; Water; proton MR spectroscopy; magnetization exchange; amides; brain; human; downfield

Purpose To develop localization sequences for in vivo MR spectroscopy (MRS) on clinical scanners of 3 T to record spectra that are not influenced by magnetization transfer from water. Methods Image‐selected in vivo spectroscopy (ISIS) localization and chemical‐shift‐selective excitation (termed I‐CS...