Reversal of Sepsis‐Like Features of Neutrophils by Interleukin‐1 Blockade in Patients With Systemic‐Onset Juvenile Idiopathic Arthritis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 70; no. 6; pp. 943 - 956
• Main Authors: Haar, Nienke M., Tak, Tamar, Mokry, Michal, Scholman, Rianne C., Meerding, Jenny M., Jager, Wilco, Verwoerd, Anouk, Foell, Dirk, Vogl, Thomas, Roth, Johannes, Leliefeld, Pieter H. C., Loosdregt, Jorg, Koenderman, Leo, Vastert, Sebastiaan J., Roock, Sytze
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2018
• Subjects: Apoptosis; Arthritis; Cytokines; Degranulation; Disease control; Flow cytometry; Fluorescence; Gene expression; Gene sequencing; Immune system; Interleukin 1 receptor antagonist; Interleukins; L-selectin; Leukocytes (neutrophilic); Neutrophils; Patients; Phenotypes; Priming; Reactive oxygen species; Remission; Ribonucleic acid; RNA; Secretory vesicles; Sepsis

Objective Neutrophils are the most abundant innate immune cells in the blood, but little is known about their role in (acquired) chronic autoinflammatory diseases. This study was undertaken to investigate the role of neutrophils in systemic‐onset juvenile idiopathic arthritis (JIA), a prototypical m...