Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study

• Published in: Human psychopharmacology Vol. 23; no. 2; pp. 87 - 94
• Main Authors: Nery, Fabiano G., Monkul, Emel S., Hatch, John P., Fonseca, Manoela, Zunta-Soares, Giovana B., Frey, Benício N., Bowden, Charles L., Soares, Jair C.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2008
• Subjects: Adult; anti-inflammatory agents; Antimanic Agents - therapeutic use; Antipsychotic Agents - therapeutic use; bipolar depression; bipolar disorder; Bipolar Disorder - drug therapy; Celecoxib; Cyclooxygenase Inhibitors - adverse effects; Cyclooxygenase Inhibitors - therapeutic use; cyclooxygenase-2 inhibitors; Double-Blind Method; Drug Therapy, Combination; Exanthema - chemically induced; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Pyrazoles - adverse effects; Pyrazoles - therapeutic use; randomized-controlled trials; Severity of Illness Index; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Time Factors

Objective To investigate whether the cox‐2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases. Methods We studied 28 DSM‐IV BD patients who were experiencing a depressive or mixed episode and were on a stable dose of a mood stabilizer o...