Multikingdom characterization of gut microbiota in patients with rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease

• Published in: Journal of medical virology Vol. 96; no. 7; pp. e29781 - n/a
• Main Authors: Xing, Yida, Liu, Yiping, Sha, Shanshan, Zhang, Yue, Dou, Yuemeng, Liu, Changyan, Xu, Mingxi, Zhao, Lin, Wang, Jingdan, Wang, Yan, Ma, Xiaochi, Yan, Qiulong, Kong, Xiaodan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2024
• Subjects: Adult; Aged; Arthritis; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - microbiology; Autoimmune diseases; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Biomarkers; Depletion; Feces; Feces - microbiology; Feces - virology; Female; Fungi - classification; Fungi - isolation & purification; Gastrointestinal Microbiome; Gut microbiota; gut virome; Humans; interstitial lung disease; Intestinal microflora; Lung diseases; Lung Diseases, Interstitial - microbiology; Lung Diseases, Interstitial - virology; Male; Microbiomes; Microbiota; microbiota dysbiosis; Microorganisms; Middle Aged; Mycobiome; Patients; Rheumatoid arthritis; Ruminococcus; Virome; Viruses - classification; Viruses - genetics; Viruses - isolation & purification; whole‐metagenome shotgun sequencing; whole‐metagenome shotgun sequencing; gut virome; microbiota dysbiosis; interstitial lung disease; rheumatoid arthritis; gut microbiota

Rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is a serious and common extra‐articular disease manifestation. Patients with RA‐ILD experience reduced bacterial diversity and gut bacteriome alterations. However, the gut mycobiome and virome in these patients have been largely negl...