WNT/β‐catenin signaling in liver health and disease

• Published in: Hepatology (Baltimore, Md.) Vol. 45; no. 5; pp. 1298 - 1305
• Main Authors: Thompson, Michael D., Monga, Satdarshan P. S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2007; Wiley
• Subjects: Animals; beta Catenin - physiology; Biological and medical sciences; Carcinoma, Hepatocellular - drug therapy; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver - embryology; Liver - growth & development; Liver - physiology; Liver Cirrhosis - physiopathology; Liver Diseases - physiopathology; Liver Neoplasms - physiopathology; Liver Regeneration - physiology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Other diseases. Semiology; Oxidative Stress; Signal Transduction - physiology; Wnt Proteins - physiology; Hepatic fibrosis; Pathophysiology; Wnt/β-catenin signaling pathway; Hepatic disease; Malignant tumor; Signalling; Stress; Anatomic pathology; Liver tumor; β Catenin; Fibrosis; Digestive diseases; Physiology; Cancer

Wnt/β‐catenin signaling is emerging as a forerunner for its critical roles in many facets of human biology. Its roles in embryogenesis, organogenesis, and maintaining tissue and organ homeostasis demonstrate its munificent character. Its roles in pathological conditions such as cancer and other huma...