Influence of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine in adult patients receiving CHOP therapy

• Published in: Cancer chemotherapy and pharmacology Vol. 92; no. 5; pp. 391 - 398
• Main Authors: Nakagawa, Junichi, Takahata, Takenori, Chen, Yu, Saito, Kensuke, Kamata, Kosuke, Tachita, Takuto, Yamashita, Satoru, Saito, Keigo, Ueno, Kayo, Sato, Atsushi, Sakuraba, Hirotake, Niioka, Takenori
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2023; Springer Nature B.V
• Subjects: adults; Cancer Research; Gene polymorphism; genotype; half life; Medicine; Medicine & Public Health; Oncology; Original Article; Pharmacokinetics; Pharmacology/Toxicology; Regression analysis; therapeutics; Vincristine; polymorphism; Pharmacokinetics; Vincristine (VCR); Adult patients; CHOP therapy

Purpose This study aims to clarify the impact of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine (VCR) in adult patients receiving CHOP therapy. Methods Plasma samples were collected immediately after the end of VCR administration and at 1.5, 2.5, 3.5, 5.5, 9.5, 13.5, and 25.5 ...