SARS‐CoV‐2 NSP7 inhibits type I and III IFN production by targeting the RIG‐I/MDA5, TRIF, and STING signaling pathways - Deng, Jian; Zheng, Yi; Zheng, Sheng‐Nan; Nan, Mei‐Ling; Han, Lulu; Zhang, Jing; Jin, Yunyun; Pan, Ji‐An; Gao, Chengjiang; Wang, Pei‐Hui (Journal of medical virology, 2023)
Keywords: Adaptor Proteins, Vesicular Transport - genetics; Antiviral drugs; cGAS; Complex formation; Coronaviruses; COVID-19; Double-stranded RNA; Ectopic expression; Humans; IFN; Immune response; Immunity; Immunity, Innate; Interferon; Interferon regulatory factor 3; Interferon Type I; Interferons; MAVS; NSP7; Nuclear transport; Nucleotidyltransferases - metabolism; Phosphorylation; Polyinosinic:polycytidylic acid; RIG‐I; SARS-CoV-2 - metabolism; SARS‐CoV‐2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signal Transduction; Signaling; STING; TLR3; TLR3 protein; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - metabolism; Toll-like receptors; Transfection; Translocation; Viral diseases; Virology; Viruses; COVID-19; IFN; MAVS; SARS-CoV-2; NSP7; cGAS; RIG-I; STING; TLR3