Non-Coding RNA Analysis Using the Rfam Database

• Published in: Current protocols in bioinformatics Vol. 62; no. 1; p. e51
• Main Authors: Kalvari, Ioanna, Nawrocki, Eric P, Argasinska, Joanna, Quinones-Olvera, Natalia, Finn, Robert D, Bateman, Alex, Petrov, Anton I
• Format: Journal Article
• Language: English
• Published: United States 01.06.2018
• Subjects: Base Sequence; Databases, Nucleic Acid; Genome, Human; Humans; Molecular Sequence Annotation; Nucleic Acid Conformation; Riboswitch - genetics; RNA, Untranslated - chemistry; RNA, Untranslated - genetics; Sequence Alignment; Sequence Analysis, RNA; RNA family; non-coding RNA; genome annotation; Infernal; Rfam

Rfam is a database of non-coding RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. Using a combination of manual and literature-based curation and a custom software pipeline, Rfam converts descriptions of RNA f...