Tumor Necrosis Factor Receptor–Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c‐Myc Gene Expression and Protein Stability

• Published in: Hepatology (Baltimore, Md.) Vol. 71; no. 1; pp. 148 - 163
• Main Authors: Wu, Hua, Yang, Tian‐Yu, Li, Yi, Ye, Wen‐Long, Liu, Feng, He, Xiao‐Shun, Wang, Jing‐Ru, Gan, Wen‐Juan, Li, Xiu‐Ming, Zhang, Shen, Zhao, Yuan‐Yuan, Li, Jian‐Ming
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.01.2020
• Subjects: Acetylation; Gene expression; Genetic transformation; Heat shock; Hepatitis B; Hepatocellular carcinoma; Hepatology; Histone deacetylase; Histone H3; Liver cancer; Myc protein; Necrosis; Prognosis; Proteins; siRNA; TRAF6 protein; Transgenic mice; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumorigenesis; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination

The oncogene c‐Myc is aberrantly expressed and plays a key role in malignant transformation and progression of hepatocellular carcinoma (HCC). Here, we report that c‐Myc is significantly up‐regulated by tumor necrosis factor receptor–associated factor 6 (TRAF6), an E3 ubiquitin ligase, in hepatocarc...