Genetic polymorphism and decreased expression of HLA class II DP genes are associated with HBV reactivation in patients treated with immunomodulatory agents

• Published in: Journal of medical virology Vol. 90; no. 4; pp. 712 - 720
• Main Authors: Matsuda, Hidetaka, Hiramatsu, Katsushi, Akazawa, Yu, Nosaka, Takuto, Saito, Yasushi, Ozaki, Yoshihiko, Hayama, Ryoko, Takahashi, Kazuto, Naito, Tatsushi, Ofuji, Kazuya, Ohtani, Masahiro, Nemoto, Tomoyuki, Hida, Yukio, Kimura, Hideki, Soya, Yoshihiro, Nakamoto, Yasunari
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: Actin; Activation; Aged; Alleles; Chemotherapy; Confidence intervals; Female; Gene expression; Gene frequency; Gene polymorphism; Genes; Genotypes; Hepatitis; Hepatitis B; hepatitis B virus; Hepatitis B, Chronic - genetics; Histocompatibility antigen HLA; HLA-DP alpha-Chains - genetics; HLA-DP beta-Chains - genetics; Humans; Immunomodulation; Immunomodulators; Immunosuppressive agents; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Infections; Male; MHC‐restricted cytotoxicity; Middle Aged; Patients; Polymorphism; Polymorphism, Genetic; reactivation; Retrospective Studies; Single-nucleotide polymorphism; Statistical analysis; Virology; Virus Activation; Viruses; MHC-restricted cytotoxicity; reactivation; hepatitis B virus

Hepatitis B virus (HBV) reactivation can be triggered by immunosuppressive chemotherapy. HLA class II molecules may play a role in HBV reactivation. Genetic polymorphism and mRNA expression of HLA class II were examined in patients with latent HBV infection treated with immunosuppressive therapies....