Type 1 diabetes mellitus: Complex interplay of oxidative stress, cytokines, gastrointestinal motility and small intestinal bacterial overgrowth

• Published in: European journal of clinical investigation Vol. 48; no. 11; pp. e13021 - n/a
• Main Authors: Malik, Aastha, Morya, Rajesh Kumar, Bhadada, Sanjay Kumar, Rana, Satyavati
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2018
• Subjects: Adolescent; Adult; Antioxidants - physiology; Bacteria; Case-Control Studies; Catalase; Catalase - metabolism; Correlation; Cytokines; Cytokines - metabolism; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - etiology; Diabetes Mellitus, Type 1 - physiopathology; Digestive system; Disease control; Enzyme-linked immunosorbent assay; Female; Gastric motility; Gastrointestinal Microbiome - physiology; gastrointestinal motility; Gastrointestinal Motility - physiology; Gastrointestinal tract; Glutathione; Glycated Hemoglobin A - metabolism; Health risks; Hemoglobin; Humans; Hyperglycemia; Hyperglycemia - complications; Inflammation; inflammatory cytokines; Interleukins; Intestine; Intestine, Small - microbiology; Lactulose; Lipid peroxidation; Lipid Peroxidation - physiology; Lipids; Male; Males; Measurement methods; Microbiota - physiology; Motility; Oxidants; Oxidation; Oxidative stress; Oxidative Stress - physiology; Oxidizing agents; Parameters; Patients; Peroxidation; Plasma levels; Risk analysis; Risk factors; small intestinal bacterial overgrowth; Superoxide dismutase; Superoxide Dismutase - metabolism; Transit time; Tumor necrosis factor; type 1 diabetes mellitus; Young Adult; gastrointestinal motility; type 1 diabetes mellitus; inflammatory cytokines; small intestinal bacterial overgrowth; oxidative stress

Background Oxidative stress is risk factor in progression of diabetes. It can increase cytokine production via several different mechanisms. Inflammation can affect gut neural apparatus that may lead to dysmotility which may exaggerate occurrence of bacterial overgrowth in intestine. Thus, a study w...