PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential - Velmurugan, Bharath K.; Lee, Chien‐Hung; Chiang, Shang‐Lun; Hua, Chun‐Hung; Chen, Mei‐Chung; Lin, Shu‐Hui; Yeh, Kun‐Tu; Ko, Ying‐Chin (Journal of cellular physiology, 2018)
Keywords: Activation; Adult; Aged; Aged, 80 and over; Antineoplastic Agents - pharmacology; Calyculin‐A; Cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; Cell Proliferation - drug effects; Deactivation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators - pharmacology; Female; Fingolimod Hydrochloride - pharmacology; FTY720; Glycogen Synthase Kinase 3 beta - metabolism; GSK‐3β; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - enzymology; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Humans; Kaplan-Meier Estimate; Logistic Models; Lymph; Lymph nodes; Lymphatic system; lymphnode metastasis; Male; Metastases; Metastasis; Middle Aged; Mouth Neoplasms - drug therapy; Mouth Neoplasms - enzymology; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Multivariate Analysis; Neoplasm Staging; Odds Ratio; Oral cancer; Oral squamous cell carcinoma; OSCC; Phosphatase; Phosphoprotein phosphatase; Phosphorylation; PP2A; Proportional Hazards Models; Protein phosphatase; Protein Phosphatase 2 - metabolism; Restoration; Risk Factors; Signal Transduction - drug effects; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; Survival; Target detection; Time Factors; Tumor suppressor genes; Tyrosine; GSK-3β; OSCC; PP2A; lymphnode metastasis; Calyculin-A; FTY720