Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells

• Published in: Journal of biochemical and molecular toxicology Vol. 35; no. 1; pp. e22611 - n/a
• Main Authors: Qian, Shengqiang, Fang, Huiying, Zheng, Lu, Liu, Mei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2021
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Akt/mTOR pathway; Antioxidants; Apoptosis; Carcinogens; Cell adhesion; Cell adhesion & migration; Cell death; Cell migration; Cell proliferation; Cell viability; Clinical trials; Deprivation; Fluorescence; Functional foods & nutraceuticals; Ginger; In vivo methods and tests; Membrane potential; Metastases; Metastasis; Mitochondria; Phenolic compounds; Phenols; Principles; Prostate cancer; Reactive oxygen species; Signal transduction; Signaling; TOR protein; Zingerone; Zingiber officinale; Akt/mTOR pathway; apoptosis; prostate cancer; zingerone; cell adhesion

Prostate cancer (PCa) is both the foremost and second cause of cancer death in the male population. Patients with hormone‐dependent PCa are initially sensitive to androgen‐deprivation therapy, later the cancer progress to a hormone‐independent state and fails to respond and progress to the metastati...