17β‐Estradiol inhibits testosterone‐induced cell proliferation in HepG2 by modulating the relative ratios of 3 estrogen receptor isoforms to the androgen receptor - Xu, Zhixiang; Liu, Jun; Jianxin, Cao; Yongliang, Zhuang; Pan, Xuejun (Journal of cellular biochemistry, 2018)
Keywords: 17β-Estradiol; Analysis of Variance; androgen receptor; Androgen receptors; Androgens; Apoptosis; Apoptosis - drug effects; BAX protein; Carcinoma, Hepatocellular - metabolism; Cell cycle; cell cycle and apoptosis; Cell Cycle Checkpoints - drug effects; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Combined treatment; cytotoxicity; Estradiol - pharmacology; Estrogen Receptor alpha; Estrogen receptors; Estrogens; Estrogens - pharmacology; Flow cytometry; G1 phase; Gene expression; Hep G2 Cells; Hepatocellular carcinoma; Hormones; Humans; Isoforms; Kinases; Liver; Liver cancer; Liver Neoplasms - metabolism; Male; Polymerase chain reaction; Protein Isoforms - metabolism; Proteins; Receptors; Receptors, Androgen - metabolism; Receptors, Estrogen - metabolism; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Sex hormones; Signal Transduction - drug effects; Testosterone; Testosterone - pharmacology; Transcription; Tumorigenesis; 17β-estradiol; androgen receptor; testosterone; estrogen receptors; cytotoxicity; cell cycle and apoptosis