Up‐regulation of NADPH oxidase components and increased production of interferon‐gamma by leukocytes from sickle cell disease patients

• Published in: American journal of hematology Vol. 83; no. 1; pp. 41 - 45
• Main Authors: Marçal, Lívia E., Dias‐da‐Motta, Péricles M., Rehder, Jussara, Mamoni, Ronei L., Blotta, Maria Heloísa S.L., Whitney, Constance B., Newburger, Peter E., Costa, Fernando F., Saad, Sara T.O., Condino‐Neto, Antonio
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2008; Wiley-Liss
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - metabolism; Anemias. Hemoglobinopathies; Biological and medical sciences; Diseases of red blood cells; Female; Gene Expression Regulation, Enzymologic; Hematologic and hematopoietic diseases; Humans; Interferon-gamma - biosynthesis; Isoenzymes - genetics; Isoenzymes - metabolism; Leukocytes - metabolism; Male; Medical sciences; Middle Aged; NADPH Oxidases - genetics; NADPH Oxidases - metabolism; Phosphorylation; RNA, Messenger - genetics; Transcription, Genetic - genetics; Tumor Necrosis Factor-alpha - biosynthesis; Up-Regulation; Human; Hemoglobinopathy; Immunopathology; Hemolytic anemia; Sickle cell anemia; Hematology; Hemopathy; Biosynthesis; Leukocyte disease; NAD(P)H oxidase; Genetic disease; Gamma interferon

We have previously demonstrated that mononuclear leukocytes from patients with sickle cell disease (SCD) release higher amounts of superoxide compared with normal controls. The aim of this study was to further study the NADPH oxidase system in these patients by investigating gene expression of NADPH...