Nicotinamide phosphoribosyltransferase secreted from microglia via exosome during ischemic injury

• Published in: Journal of neurochemistry Vol. 150; no. 6; pp. 723 - 737
• Main Authors: Lu, Yun‐Bi, Chen, Chen‐Xiang, Huang, Jing, Tian, Yu‐Xin, Xie, Xian, Yang, Ping, Wu, Ming, Tang, Chun, Zhang, Wei‐Ping
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2019
• Subjects: Adenine; Animals; Autophagy; Brain - metabolism; Brain Ischemia - metabolism; Butanol; Calcium (intracellular); Calcium ions; Centrifugation; Cytokines - metabolism; Deprivation; Electron microscopy; Endosomes; exosome; Exosomes - metabolism; Glucose - deficiency; Golgi apparatus; Hypoxia; Inflammation; Injuries; Ischemia; ischemic injury; Microglia; Microglia - metabolism; Morphology; NAD; neuroinflammation; Nicotinamide; Nicotinamide adenine dinucleotide; Nicotinamide phosphoribosyltransferase; Nicotinamide Phosphoribosyltransferase - metabolism; Phagocytosis; Phospholipase; Phospholipase D; Phosphoribosyltransferase; Physical characteristics; Rats; Rats, Sprague-Dawley; siRNA; Vesicles; Western blotting; Wortmannin; nicotinamide phosphoribosyltransferase; neuroinflammation; exosome; microglia; ischemic injury

Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the salvage pathway of nicotinamide adenine dinucleotide synthesis. NAMPT can also be secreted and functions as a cytokine. We have previously shown that in the brain, NAMPT expression and secretion can be induced in microglia upon...