Synthesis, characterization and antibacterial activity of juglone encapsulated PLGA nanoparticles

• Published in: Journal of applied microbiology Vol. 123; no. 6; pp. 1407 - 1419
• Main Authors: Arasoglu, T., Derman, S., Mansuroglu, B., Yelkenci, G., Kocyigit, B., Gumus, B., Acar, T., Kocacaliskan, I.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2017
• Subjects: Alcohols; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antimicrobial activity; Antimicrobial agents; antimicrobials; Bacteria; Bacteria - drug effects; biodegradation; biopolymers; Chemical synthesis; Controlled release; Drug Compounding; E. coli; Encapsulation; Formulations; Free form; Gram-negative bacteria; Gram-positive bacteria; Juglone; Microbial Sensitivity Tests; Minimum inhibitory concentration; Nanoparticles; Nanoparticles - chemistry; Naphthoquinones - chemistry; Naphthoquinones - pharmacology; Particle Size; Polydispersity; Polyglycolic Acid - chemistry; Polylactide-co-glycolide; Polyvinyl alcohol; Process parameters; Staphylococci; Toxicity; Zeta potential; Staphylococci; biodegradation; E. coli; antimicrobials; biopolymers

Aims The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l‐lactide co‐glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l‐lactide co‐glycolide) nanop...