Synthesis, characterization and antibacterial activity of juglone encapsulated PLGA nanoparticles
Aims The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l‐lactide co‐glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l‐lactide co‐glycolide) nanop...
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Published in | Journal of applied microbiology Vol. 123; no. 6; pp. 1407 - 1419 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.12.2017
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Subjects | |
Online Access | Get full text |
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Abstract | Aims
The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l‐lactide co‐glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l‐lactide co‐glycolide) nanoparticles.
Methods and Results
The synthesized nanoparticle formulations were analyzed for reaction yield, encapsulation efficiency, particle size, polydispersity, zeta potential and juglone release. In conjunction with the highest encapsulation rate, the highest amount of juglone release was obtained for F4 formulation, which has 281·8 nm particle size, 0·217 polydispersity index, and −19·55 mV zeta potential. After the detailed physicochemical characterization of this formulation, the four different kinetic models were used and it was found that juglone release mechanism controlled by Fickian diffusion method. According to antimicrobial activity results, minimal inhibitory concentration (MIC) values of both F4 and free juglone is higher for Gram negative bacteria than Gram positive bacteria. Inhibition zone diameters in the quantitative methods are found 15 and 16 mm for Staphylococcus aureus, 9 and 7 mm for Bacillus cereus, respectively, for F4 and free juglone. Moreover, the MIC values for qualitative methods were found 31·5 μg ml−1 for two bacteria strains.
Conclusions
It was found that the antibacterial activity of the juglone nanoparticles was higher and longer than the free juglone. Additionally, a similar antimicrobial effect with a lower juglone amount (obtained from controlled release study) indicates that nanoparticle formulation is more effective.
Significance and Impact of the Study
The use of nanoparticle formulations of juglone in biological systems and applications could be more beneficial than its free form due to its toxicity. |
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AbstractList | Aims
The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l‐lactide co‐glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l‐lactide co‐glycolide) nanoparticles.
Methods and Results
The synthesized nanoparticle formulations were analyzed for reaction yield, encapsulation efficiency, particle size, polydispersity, zeta potential and juglone release. In conjunction with the highest encapsulation rate, the highest amount of juglone release was obtained for F4 formulation, which has 281·8 nm particle size, 0·217 polydispersity index, and −19·55 mV zeta potential. After the detailed physicochemical characterization of this formulation, the four different kinetic models were used and it was found that juglone release mechanism controlled by Fickian diffusion method. According to antimicrobial activity results, minimal inhibitory concentration (MIC) values of both F4 and free juglone is higher for Gram negative bacteria than Gram positive bacteria. Inhibition zone diameters in the quantitative methods are found 15 and 16 mm for Staphylococcus aureus, 9 and 7 mm for Bacillus cereus, respectively, for F4 and free juglone. Moreover, the MIC values for qualitative methods were found 31·5 μg ml−1 for two bacteria strains.
Conclusions
It was found that the antibacterial activity of the juglone nanoparticles was higher and longer than the free juglone. Additionally, a similar antimicrobial effect with a lower juglone amount (obtained from controlled release study) indicates that nanoparticle formulation is more effective.
Significance and Impact of the Study
The use of nanoparticle formulations of juglone in biological systems and applications could be more beneficial than its free form due to its toxicity. The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l-lactide co-glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l-lactide co-glycolide) nanoparticles. The synthesized nanoparticle formulations were analyzed for reaction yield, encapsulation efficiency, particle size, polydispersity, zeta potential and juglone release. In conjunction with the highest encapsulation rate, the highest amount of juglone release was obtained for F4 formulation, which has 281·8 nm particle size, 0·217 polydispersity index, and -19·55 mV zeta potential. After the detailed physicochemical characterization of this formulation, the four different kinetic models were used and it was found that juglone release mechanism controlled by Fickian diffusion method. According to antimicrobial activity results, minimal inhibitory concentration (MIC) values of both F4 and free juglone is higher for Gram negative bacteria than Gram positive bacteria. Inhibition zone diameters in the quantitative methods are found 15 and 16 mm for Staphylococcus aureus, 9 and 7 mm for Bacillus cereus, respectively, for F4 and free juglone. Moreover, the MIC values for qualitative methods were found 31·5 μg ml for two bacteria strains. It was found that the antibacterial activity of the juglone nanoparticles was higher and longer than the free juglone. Additionally, a similar antimicrobial effect with a lower juglone amount (obtained from controlled release study) indicates that nanoparticle formulation is more effective. The use of nanoparticle formulations of juglone in biological systems and applications could be more beneficial than its free form due to its toxicity. Aims The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l-lactide co-glycolide) amount, polyvinyl alcohol volume and polyvinyl alcohol concentration on encapsulation of juglone to poly(d,l-lactide co-glycolide) nanoparticles. Methods and Results The synthesized nanoparticle formulations were analyzed for reaction yield, encapsulation efficiency, particle size, polydispersity, zeta potential and juglone release. In conjunction with the highest encapsulation rate, the highest amount of juglone release was obtained for F4 formulation, which has 281·8 nm particle size, 0·217 polydispersity index, and -19·55 mV zeta potential. After the detailed physicochemical characterization of this formulation, the four different kinetic models were used and it was found that juglone release mechanism controlled by Fickian diffusion method. According to antimicrobial activity results, minimal inhibitory concentration (MIC) values of both F4 and free juglone is higher for Gram negative bacteria than Gram positive bacteria. Inhibition zone diameters in the quantitative methods are found 15 and 16 mm for Staphylococcus aureus, 9 and 7 mm for Bacillus cereus, respectively, for F4 and free juglone. Moreover, the MIC values for qualitative methods were found 31·5 µg ml-1 for two bacteria strains. Conclusions It was found that the antibacterial activity of the juglone nanoparticles was higher and longer than the free juglone. Additionally, a similar antimicrobial effect with a lower juglone amount (obtained from controlled release study) indicates that nanoparticle formulation is more effective. Significance and Impact of the Study The use of nanoparticle formulations of juglone in biological systems and applications could be more beneficial than its free form due to its toxicity. |
Author | Yelkenci, G. Kocyigit, B. Gumus, B. Acar, T. Kocacaliskan, I. Arasoglu, T. Mansuroglu, B. Derman, S. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28980369$$D View this record in MEDLINE/PubMed |
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Copyright | 2017 The Society for Applied Microbiology 2017 The Society for Applied Microbiology. Copyright © 2017 The Society for Applied Microbiology |
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The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l‐lactide... The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l-lactide co-glycolide)... Aims The aim of the study was to examine the effect of different process parameters which including; initial juglone amount, initial poly(d,l-lactide... |
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SubjectTerms | Alcohols Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antimicrobial activity Antimicrobial agents antimicrobials Bacteria Bacteria - drug effects biodegradation biopolymers Chemical synthesis Controlled release Drug Compounding E. coli Encapsulation Formulations Free form Gram-negative bacteria Gram-positive bacteria Juglone Microbial Sensitivity Tests Minimum inhibitory concentration Nanoparticles Nanoparticles - chemistry Naphthoquinones - chemistry Naphthoquinones - pharmacology Particle Size Polydispersity Polyglycolic Acid - chemistry Polylactide-co-glycolide Polyvinyl alcohol Process parameters Staphylococci Toxicity Zeta potential |
Title | Synthesis, characterization and antibacterial activity of juglone encapsulated PLGA nanoparticles |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjam.13601 https://www.ncbi.nlm.nih.gov/pubmed/28980369 https://www.proquest.com/docview/1963844933/abstract/ |
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