Pharmacodynamics and pharmacokinetics of DWP14012 (fexuprazan) in healthy subjects with different ethnicities

• Published in: Alimentary pharmacology & therapeutics Vol. 52; no. 11-12; pp. 1648 - 1657
• Main Authors: Hwang, Jun Gi, Jeon, Inseung, Park, Sun Ae, Lee, Areum, Yu, Kyung‐Sang, Jang, In‐Jin, Lee, SeungHwan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2020
• Subjects: Acids; Adult; Amines - administration & dosage; Amines - pharmacokinetics; Amines - pharmacology; Antacids; Asian Continental Ancestry Group; Double-Blind Method; Ethnicity; European Continental Ancestry Group; Female; Gastric Acid - metabolism; Gastric juice; Gastrin; Humans; Male; Minority & ethnic groups; pH effects; Pharmacodynamics; Pharmacokinetics; Pyrroles - administration & dosage; Pyrroles - pharmacokinetics; Pyrroles - pharmacology; Young Adult

Summary Background DWP14012 (fexuprazan), a novel potassium‐competitive acid blocker, is under development for the treatment of acid‐related disorders. Aims To compare the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of DWP14012 among healthy subjects of Korean, Caucasian and Japanese d...