Copper promotes the migration of bone marrow mesenchymal stem cells via Rnd3‐dependent cytoskeleton remodeling

• Published in: Journal of cellular physiology Vol. 235; no. 1; pp. 221 - 231
• Main Authors: Chen, Xi, Hu, Jun‐Gen, Huang, Yi‐Zhou, Li, Shun, Li, Sheng‐Fu, Wang, Min, Xia, Hong‐Wei, Li‐Ling, Jesse, Xie, Hui‐Qi
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2020
• Subjects: Bone marrow; cell migration; Copper; Cytoskeleton; Esophagus; Gene expression; Guanosine triphosphatases; Homing; Hypoxia; In vivo methods and tests; Mesenchymal stem cells; Mesenchyme; Motility; mRNA; Proteins; Recruitment; Regenerative medicine; Rnd3; siRNA; Stem cells; Tissue engineering; cell migration; copper; cytoskeleton; Rnd3; mesenchymal stem cells

The motility of mesenchymal stem cells (MSCs) is highly related to their homing in vivo, a critical issue in regenerative medicine. Our previous study indicated copper (Cu) might promote the recruitment of endogenous MSCs in canine esophagus defect model. In this study, we investigated the effect of...