Genetic polymorphism in the tumour necrosis factor alpha gene (G‐308A) is associated with persistent apical periodontitis in Brazilians

• Published in: International endodontic journal Vol. 56; no. 1; pp. 17 - 26
• Main Authors: Castro, Guilherme Assed Piedade, Petean, Igor Bassi Ferreira, Paula‐Silva, Francisco Wanderley Garcia, Kuchler, Erika Calvano, Antunes, Leonardo dos Santos, Segato, Raquel Assed Bezerra, Silva, Lea Assed Bezerra, Silva‐Sousa, Alice Corrêa, Sousa‐Neto, Manoel Damião
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2023
• Subjects: Alleles; apical periodontitis; Endodontics; Gene frequency; Gene polymorphism; genetic polymorphisms; genetics; Genotyping; Gum disease; immune‐inflammatory response; Periodontitis; Polymorphism; Root canals; Saliva; Tumor necrosis factor; Tumor necrosis factor receptors; Tumor necrosis factor-TNF; Tumors; tumour necrosis factor; tumour necrosis factor; genetics; apical periodontitis; genetic polymorphisms; immune-inflammatory response

Aim To investigate if there was an association between genetic polymorphisms in tumour necrosis factor (TNF)‐⍺ and its receptors TNFRSF1A and TNFRSF1B with persistent apical periodontitis (PAP) in Brazilian subjects. Methodology Patients who had pulpal necrosis and apical periodontitis at the time o...