Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology

• Published in: Hepatology (Baltimore, Md.) Vol. 48; no. 2; pp. 541 - 549
• Main Authors: Newton, Julia L., Hollingsworth, Kieren G., Taylor, Roy, El‐Sharkawy, Ahmed M., Khan, Zia Uda, Pearce, Ruth, Sutcliffe, Kathryn, Okonkwo, Oke, Davidson, Adrian, Burt, Jennifer, Blamire, Andrew M., Jones, David
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2008; Wiley
• Subjects: Aged; Autonomic Nervous System Diseases - etiology; Autonomic Nervous System Diseases - physiopathology; Baroreflex; Biological and medical sciences; Brain - pathology; Cognition; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Cognition Disorders - etiology; Cognition Disorders - psychology; Cohort Studies; Female; Gastroenterology. Liver. Pancreas. Abdomen; Heart Rate; Humans; Liver Cirrhosis, Biliary - complications; Liver Cirrhosis, Biliary - diagnosis; Liver Cirrhosis, Biliary - physiopathology; Liver Cirrhosis, Biliary - psychology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neuropsychological Tests; Other diseases. Semiology; Prevalence; Sickness Impact Profile; Time Factors; Primary biliary cirrhosis; Symptomatology; Cognitive disorder; Etiology; Gastroenterology; Digestive diseases; Hepatic disease
• ISSN: 0270-9139; 1527-3350; 1527-3350
• DOI: 10.1002/hep.22371

Qualitative studies suggest that patients with primary biliary cirrhosis (PBC) experience significant problems with memory and concentration. Studies of nonhepatic disease have linked hypotension and cognitive impairment. In this study, we determined the prevalence of cognitive symptoms in PBC, exam...