Incidence and Risk of Glucocorticoid‐Associated Adverse Effects in Patients With Rheumatoid Arthritis

• Published in: Arthritis care & research (2010) Vol. 71; no. 4; pp. 498 - 511
• Main Authors: Wilson, Jessica C., Sarsour, Khaled, Gale, Sara, Pethö‐Schramm, Attila, Jick, Susan S., Meier, Christoph R.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2019
• Subjects: Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - mortality; Bleeding; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - epidemiology; Case-Control Studies; Cerebral infarction; Diabetes mellitus; Diabetes Mellitus - chemically induced; Diabetes Mellitus - epidemiology; Female; Gastrointestinal Hemorrhage - chemically induced; Gastrointestinal Hemorrhage - epidemiology; Glaucoma; Glaucoma - chemically induced; Glaucoma - epidemiology; Glucocorticoids; Glucocorticoids - adverse effects; Health risk assessment; Humans; Hypertension; Incidence; Intestinal Perforation - chemically induced; Intestinal Perforation - epidemiology; Male; Middle Aged; Myocardial infarction; Osteoporosis; Osteoporosis - chemically induced; Osteoporosis - epidemiology; Rheumatoid arthritis; United Kingdom - epidemiology; United Kingdom

Objective Using the UK Clinical Practice Research Datalink, we examined the incidence of glucocorticoid (GC)‐related serious adverse events (SAEs) in rheumatoid arthritis (RA) and non‐RA patients and quantified the risk of SAEs in patients with RA. Methods We matched incident patients with RA to an...