Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness

• Published in: The Journal of pathology Vol. 244; no. 2; pp. 151 - 163
• Main Authors: Leung, Thomas Ho‐Yin, Tang, Hermit Wai‐Man, Siu, Michelle Kwan‐Yee, Chan, David Wai, Chan, Karen Kar‐Loen, Cheung, Annie Nga‐Yin, Ngan, Hextan Yuen‐Sheung
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2018; Wiley Subscription Services, Inc
• Subjects: Cancer therapies; CD55; Cell migration; Cell self-renewal; Cervical cancer; Cervix; CRISPR; E6 protein; Ectopic expression; Epithelial cells; Gene expression; HPV‐E6; Human papillomavirus; Proteins; Radioresistance; Tumor cell lines; Tumors; HPV-E6; cervical cancer; CD55

Accumulating evidence indicates that the human papillomavirus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Subpopulations of cells that reside within tumours are responsible for tumour resistance to cancer therapy and recurrence. However, the identity of such cells re...