Treatment Outcomes of Intralesional Steroid Injection for Refractory Vocal Process Granuloma

• Published in: Clinical otolaryngology Vol. 49; no. 6; pp. 822 - 826
• Main Authors: Yu, Po‐Jun, Hung, Wei‐Chen, Wang, Chi‐Te
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2024
• Subjects: Adult; Aged; Botulinum toxin; Clinical outcomes; contact granuloma; contact ulcer; Female; Glucocorticoids - administration & dosage; Granuloma; Granuloma, Laryngeal - drug therapy; Granulomas; Humans; Hygiene; Injection; Injections, Intralesional; Laryngeal Diseases - drug therapy; laryngopharyngeal reflux; Male; Middle Aged; minimally invasive surgery; proton pump inhibitor; Proton pump inhibitors; Retrospective Studies; Size reduction; Steroids; Treatment Outcome; Vocal Cords - injuries; voice; voice; contact ulcer; minimally invasive surgery; proton pump inhibitor; contact granuloma; laryngopharyngeal reflux
• DOI: 10.1111/coa.14210
• ISSN: 1749-4478; 1749-4486

ABSTRACT Objectives Vocal process granuloma (VPG) is a chronic condition resulting from a mucoperichondrial injury of vocal process. Initial conservative treatment typically involves vocal hygiene education and antireflux medication. Treatment challenges arise with refractory cases. Outcomes of second‐line treatments such as surgical excision and botulinum toxin injections remain inconsistent. Thus, we propose this study to investigate the effectiveness of intralesional steroid injections for refractory VPG. Methods We conducted a retrospective review of 23 patients with VPG who showed no improvement after 3 months of proton pump inhibitors. These patients underwent one to three courses of monthly in‐office intralesional steroid injections as a second‐line therapy. Treatment outcomes were evaluated by measuring the size of the VPG relative to the length of the vocal folds before and after the final injection procedure. Results Results showed a significant reduction in VPG size from baseline of 27.74 ± 15.06 to 5.48 ± 8.95 (p < .001). 15 out of 23 patients were responsive (size reduction ≥ 75%) to intralesional steroid injection. Alcohol consumption and longer symptom duration were associated with a poor response (size reduction <75%), whereas prior intubation was associated with better response. Conclusions For refractory VPG not responding to conservative treatment, intralesional steroid injection appears to be a promising alternative option without significant adverse effects.