STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

• Published in: Nature communications Vol. 16; no. 1; pp. 7815 - 16
• Main Authors: Dong, Di, Zhou, Zhe, Zhu, Minglu, Hou, Zhiyuan, Chen, Mo, Gong, Jingjing, Zhao, Xuyang, Yan, Aohui, Liang, Hui, Yin, Yuxin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/109; 13/44; 13/51; 38/1; 38/15; 38/32; 38/39; 38/43; 38/77; 38/91; 631/67/322; 631/67/395; 631/80/304; 692/4020/1503/1712/1713; Adenocarcinoma; Cancer; Datasets; Genomes; Humanities and Social Sciences; Maintenance; Medical prognosis; Metastases; Metastasis; multidisciplinary; Pancreatic cancer; Pathogenesis; Patients; Proteins; Science; Science (multidisciplinary); Single-stranded DNA; Stat3 protein; Statistical significance; Telomeres; Therapeutic targets

Pancreatic ductal adenocarcinoma (PDAC) poses a serious clinical challenge, demanding further exploration of its pathogenesis and therapeutic targets for metastasis, the main cause of mortality. Here, we identify STN1, a CST complex member crucial for maintaining telomere lengths and genome stabilit...