Human trisomy 21 fibroblasts rescue methotrexate toxic effect after treatment with 5‐methyl‐tetrahydrofolate and 5‐formyl‐tetrahydrofolate

• Published in: Journal of cellular physiology Vol. 234; no. 9; pp. 15010 - 15024
• Main Authors: Vitale, Lorenza, Serpieri, Valentina, Lauriola, Mattia, Piovesan, Allison, Antonaros, Francesca, Cicchini, Elena, Locatelli, Chiara, Cocchi, Guido, Strippoli, Pierluigi, Caracausi, Maria
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2019
• Subjects: Biotechnology; Carbon; Carbon cycle; Cell lines; Cytotoxicity; Dihydrofolate reductase; Down's syndrome; Fibroblasts; folates; Folic acid; Genetic disorders; Intellectual disabilities; Lymphocytes; Metabolism; Methotrexate; one‐carbon metabolism; Skin; Statistical analysis; Tetrahydrofolic acid; Toxicity; Trisomy; trisomy 21; folates; methotrexate; fibroblasts; trisomy 21; one-carbon metabolism
• ISSN: 0021-9541; 1097-4652; 1097-4652
• DOI: 10.1002/jcp.28140

Trisomy 21 causes Down syndrome (DS), the most common human genetic disorder and the leading genetic cause of intellectual disability. The alteration of one‐carbon metabolism was described as the possible metabolic cause of the intellectual disability development in subjects with DS. One of the bioc...