Polyomavirus Replication and Smoking Are Independent Risk Factors for Bladder Cancer After Renal Transplantation

• Published in: Transplantation Vol. 101; no. 6; p. 1488
• Main Authors: Liu, Sandy, Chaudhry, Muhammad R, Berrebi, Alexander A, Papadimitriou, John C, Drachenberg, Cinthia B, Haririan, Abdolreza, Alexiev, Borislav A
• Format: Journal Article
• Language: English
• Published: United States 01.06.2017
• Subjects: Academic Medical Centers; Adult; Female; Humans; Immunocompromised Host; Immunosuppressive Agents - adverse effects; Incidence; Kidney Transplantation - adverse effects; Male; Maryland - epidemiology; Middle Aged; Opportunistic Infections - diagnosis; Opportunistic Infections - epidemiology; Opportunistic Infections - immunology; Opportunistic Infections - virology; Polyomavirus - growth & development; Polyomavirus - immunology; Polyomavirus Infections - diagnosis; Polyomavirus Infections - epidemiology; Polyomavirus Infections - immunology; Polyomavirus Infections - virology; Retrospective Studies; Risk Factors; Smoking - adverse effects; Time Factors; Treatment Outcome; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - epidemiology; Urinary Bladder Neoplasms - immunology; Urinary Bladder Neoplasms - virology; Virus Replication

Solid organ transplant recipients are at increased risk for developing malignancies. Polyomaviruses (PV) have been historically associated with experimental tumor development and recently described in association with renourinary malignancies in transplant patients. The aim of this study was to inve...