Critical appraisal of clinical trials in multiple system atrophy: Toward better quality

• Published in: Movement disorders Vol. 32; no. 10; pp. 1356 - 1364
• Main Authors: Castro Caldas, Ana, Levin, Johannes, Djaldetti, Ruth, Rascol, Olivier, Wenning, Gregor, Ferreira, Joaquim J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2017
• Subjects: Adult; Aged; Atrophy; Clinical trials; Clinical Trials as Topic - methods; Databases, Factual - statistics & numerical data; Female; Humans; Information processing; Male; methodology; Middle Aged; Movement disorders; multiple system atrophy; Multiple System Atrophy - therapy; Outcome Assessment, Health Care - methods; Quality; Treatment Outcome; trial design; clinical trials; multiple system atrophy; trial design; methodology

ABSTRACT Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause. Although many clinical trials have been conducted, there is still no treatment that cures the disease or slows its progression. We sought to assess the clinical trials, methodology, and quality of repor...