ETS2 alleviates acute‐on‐chronic liver failure by suppressing excessive inflammation

• Published in: Journal of medical virology Vol. 95; no. 4; pp. e28710 - n/a
• Main Authors: He, Lulu, Cai, Qun, Liang, Xi, Xin, Jiaojiao, Shi, Dongyan, Ren, Keke, Li, Yun, Chen, Jiaxian, Sun, Suwan, Guo, Beibei, Yang, Hui, Li, Bingqi, Ma, Shiwen, Luo, Jinjin, Hu, Meiqian, Li, Jiaqi, Hu, Wen, Li, Peng, Yao, Heng, Li, Jun, Chen, Xin, Jiang, Jing
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2023
• Subjects: Acute-On-Chronic Liver Failure - pathology; acute‐on‐chronic liver failure; Animals; Biomarkers; Ets-2 protein; ETS2; Failure; Gene sequencing; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; HMGB1; HMGB1 protein; HMGB1 Protein - metabolism; Humans; Immune response; Inflammation; Inflammation - metabolism; Inflammatory response; Innate immunity; Interleukin 6; Interleukin-6 - genetics; Leukocytes (mononuclear); Leukocytes (neutrophilic); Leukocytes, Mononuclear - metabolism; Lipopolysaccharides; Liver; Liver failure; Macrophages; Mice; Mice, Knockout; Monocytes; Mortality; Pathogenesis; Peripheral blood mononuclear cells; Prognosis; Therapeutic targets; Transcriptomes; Virology; Viruses; HMGB1; inflammation; prognosis; ETS2; acute-on-chronic liver failure

Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is a syndrome with high short‐term mortality. The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify the molecular basis of ETS2 in ACLF pathogenesis. Peripheral blood mononuclear cells f...