Netrin‐1 and multiple sclerosis: a new biomarker for neuroinflammation?

• Published in: European journal of neurology Vol. 24; no. 9; pp. 1108 - 1115
• Main Authors: Mulero, P., Córdova, C., Hernández, M., Martín, R., Gutiérrez, B., Muñoz, J. C., Redondo, N., Gallardo, I., Téllez, N., Nieto, M. L.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.09.2017
• Subjects: Adult; Aged; Animals; Axon guidance; Biomarkers; Blood-brain barrier; Central nervous system; Cerebellum - metabolism; Encephalomyelitis, Autoimmune, Experimental - blood; Encephalomyelitis, Autoimmune, Experimental - diagnosis; Enzyme-Linked Immunosorbent Assay; Experimental allergic encephalomyelitis; experimental autoimmune encephalomyelitis; Female; Humans; Immune system; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - metabolism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - diagnosis; Multiple Sclerosis - metabolism; Multiple Sclerosis, Relapsing-Remitting - blood; Multiple Sclerosis, Relapsing-Remitting - diagnosis; Netrin-1; Netrin-1 - blood; Netrin-1 - metabolism; Patients; Recurrence; Rodents; Serum levels; Spinal cord; Spinal Cord - metabolism; Tissues; Tumor necrosis factor; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; Young Adult; experimental autoimmune encephalomyelitis; biomarkers; multiple sclerosis; netrin-1

Background and purpose Netrin‐1, an axon guidance protein, reduces serum levels of pro‐inflammatory mediators and stabilizes the blood−brain barrier limiting the entrance of immune cells into the central nervous system. The aim was to investigate its presence in the experimental autoimmune encephalo...