S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT

• Published in: Human psychopharmacology Vol. 23; no. 7; pp. 549 - 554
• Main Authors: Heinzel, Alexander, Steinke, Rainer, Poeppel, Thorsten Dirk, Grosser, Oliver, Bogerts, Bernhard, Otto, Hans, Northoff, Georg
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2008
• Subjects: Adult; Analysis of Variance; Anesthetics, Dissociative - blood; Anesthetics, Dissociative - pharmacology; Brain Mapping; Brief Psychiatric Rating Scale; Case-Control Studies; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - drug effects; Female; Flumazenil - analogs & derivatives; GABA-A; Humans; Hydrocortisone - blood; I-123-iomazenil; Iodine Radioisotopes; Ketamine - blood; Ketamine - pharmacology; Male; medial prefrontal cortex; Prolactin - blood; Receptors, GABA-A - physiology; S-ketamine; SPECT; Tomography, Emission-Computed, Single-Photon; Young Adult

Objective We aimed to probe for regional cerebral effects of S‐ketamine on in vivo GABA‐A‐receptor binding in healthy human subjects. Methods We investigated I‐123‐iomazenil SPECT before, during and after administration of S‐ketamine in a blinded placebo‐controlled study design (n = 12 in both group...