Asthma diagnosis using integrated analysis of eosinophil microRNAs

• Published in: Allergy (Copenhagen) Vol. 74; no. 3; pp. 507 - 517
• Main Authors: Rodrigo‐Muñoz, José M., Cañas, José A., Sastre, Beatriz, Rego, Natalia, Greif, Gonzalo, Rial, Manuel, Mínguez, Pablo, Mahíllo‐Fernández, Ignacio, Fernández‐Nieto, Mar, Mora, Inés, Barranco, Pilar, Quirce, Santiago, Sastre, Joaquín, Pozo, Victoria
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.03.2019
• Subjects: Asthma; Asthma - blood; Asthma - diagnosis; Asthma - etiology; biomarker; Biomarkers; Case-Control Studies; Computational Biology - methods; Diagnosis; eosinophil; Eosinophils - immunology; Eosinophils - metabolism; Female; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Humans; Leukocytes (eosinophilic); Male; Medical diagnosis; microRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Real-Time Polymerase Chain Reaction; Regression analysis; Reproducibility of Results; Respiratory tract; Respiratory tract diseases; ROC Curve; Severity of Illness Index; diagnosis; microRNA; asthma; biomarker; eosinophil

Background Asthma is a syndrome characterized by airway inflammation and obstruction. Due to its heterogeneity, the difficulties in asthma diagnosis and treatment make the discovery of new biomarkers a focus of research. So, we determined the differential miRNA expression of eosinophils between heal...