Acquired von Willebrand syndrome: Diagnostic problems and therapeutic options

• Published in: American journal of hematology Vol. 82; no. 1; pp. 55 - 58
• Main Authors: Eikenboom, Jeroen C.J., Tjernberg, Pernilla, Van Marion, Vincent, Heering, Karel J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2007; Wiley-Liss
• Subjects: Aged; Biological and medical sciences; Diagnosis, Differential; Hematologic and hematopoietic diseases; Hemorrhage - blood; Hemorrhage - diagnosis; Hemorrhage - drug therapy; Hemorrhage - etiology; Humans; immunoglobulin; Immunoglobulins, Intravenous - administration & dosage; Immunologic Factors - administration & dosage; Male; Medical sciences; Platelet diseases and coagulopathies; propeptide; Syndrome; von Willebrand disease; von Willebrand Diseases - blood; von Willebrand Diseases - diagnosis; von Willebrand Diseases - drug therapy; von Willebrand Diseases - etiology; von Willebrand factor; von Willebrand Factor - analysis; Immunoglobulins; Hematology; immunoglobulin; Acquired; Willebrand disease; Propeptide; Hemopathy; Genetic disease; Treatment; von Willebrand factor; von Willebrand disease; Diagnosis; Willebrand factor; Coagulopathy

We present a case of acquired von Willebrand syndrome (AVWS) due to a monoclonal gammopathy of undetermined significance. Initially this case was diagnosed as congenital von Willebrand disease (VWD); however, re‐examination of the medical history rendered a congenital bleeding disorder unlikely. A n...