Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus

• Published in: Diabetes/metabolism research and reviews Vol. 39; no. 4; pp. e3620 - n/a
• Main Authors: Tang, Wenjuan, Ge, Kang, Shen, Lei, Wang, Hongdong, Feng, Wenhuan, Sun, Xitai, Chu, Xuehui, Zhu, Dalong, Yin, Hongli, Bi, Yan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2023
• Subjects: Biopsy; Cell culture; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Flow cytometry; Gene expression; Gluconeogenesis; Glucose metabolism; hepatic gluconeogenesis; Hepatocytes; Humans; Hyperglycemia; Immunoregulation; Interferon; interferon‐γ; Interleukin 17; Liver; Lymphocytes T; Mucosa; Mucosal-Associated Invariant T Cells - physiology; mucosal‐associated invariant T cells; Pyruvate carboxylase; Pyruvic acid; Tumor necrosis factor; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; tumour necrosis factor‐α; type 2 diabetes mellitus; mucosal-associated invariant T cells; type 2 diabetes mellitus; tumour necrosis factor-α; hepatic gluconeogenesis; interferon-γ

Aims It is acknowledged that aberrant liver immunity contributes to the development of type 2 diabetes mellitus (T2DM). Mucosal‐associated invariant T (MAIT) cells, an innate‐like T‐cell subset, are enriched in the human liver. Nevertheless, the characterisation and potential role of hepatic MAIT ce...