The Neuroprotective Role of MiR‐124‐3p in a 6‐Hydroxydopamine‐Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5

• Published in: Journal of cellular biochemistry Vol. 119; no. 1; pp. 269 - 277
• Main Authors: Dong, Rui‐Fang, Zhang, Bing, Tai, Li‐Wen, Liu, Hong‐Mei, Shi, Fang‐Kun, Liu, Ning‐Ning
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: 6-Hydroxydopamine; 6‐OHDA; Animals; Annexin A5 - biosynthesis; Annexin A5 - genetics; ANXA5; Apoptosis; Caspase; Caspase-3; Chromosome 3; Dopamine receptors; Gene expression; Gene Expression Regulation - drug effects; Mesencephalon; Metabolic pathways; MicroRNAs - biosynthesis; MicroRNAs - genetics; miR‐124‐3p; Models, Biological; Movement disorders; Neurodegenerative diseases; Neuroprotection; Neurotoxicity; Oxidative stress; Oxidopamine - adverse effects; Oxidopamine - pharmacology; Parkinson Disease, Secondary - chemically induced; Parkinson Disease, Secondary - genetics; Parkinson Disease, Secondary - metabolism; Parkinson Disease, Secondary - pathology; PARKINSON'S DISEASE; PC12 Cells; Pheochromocytoma cells; Post-transcription; Protein folding; Rats; 6-OHDA; miR-124-3p; PARKINSON'S DISEASE; ANXA5

ABSTRACT Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by a progressive loss of dopaminergic neurons in the midbrain. Several pathogenetic factors have been involved in the onset and progression of PD, including inflammation, oxidative stress, unf...