A cellular perspective of adipogenesis transcriptional regulation

Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempt...

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Published inJournal of cellular physiology Vol. 234; no. 2; pp. 1111 - 1129
Main Authors Kuri‐Harcuch, Walid, Velez‐delValle, Cristina, Vazquez‐Sandoval, Alfredo, Hernández‐Mosqueira, Claudia, Fernandez‐Sanchez, Veronica
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.02.2019
Subjects
3T3-L1 Cells
3T3‐F442A
3T3‐L1
adipocyte
Adipocytes
Adipocytes - metabolism
Adipogenesis
Adipogenesis - genetics
Animals
Cell culture
Cell differentiation
Cell lines
Cytoplasm
Differentiation (biology)
Energy metabolism
Fat metabolism
Gene regulation
Humans
Lipids
Metabolism
Mice
Secretion
Signal Transduction
staurosporine
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
transcriptional regulation
cell differentiation
staurosporine
adipogenesis
3T3-F442A
transcriptional regulation
adipocyte
3T3-L1
Online AccessGet full text
ISSN0021-9541
1097-4652
1097-4652
DOI10.1002/jcp.27060

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Abstract Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3‐F442A during 1974–1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3‐L1 and 3T3‐F442A cells that have provided essential data on adipose biology. In this review, we examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3 F442A and also concentrated our attention on research published during the last few years, emphasizing data described to regulate adipose differentiation, outside of those that are part of the canonical adipogenic transcriptional cascade.
AbstractList Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3‐F442A during 1974–1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3‐L1 and 3T3‐F442A cells that have provided essential data on adipose biology.
Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3‐F442A during 1974–1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3‐L1 and 3T3‐F442A cells that have provided essential data on adipose biology. In this review, we examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3 F442A and also concentrated our attention on research published during the last few years, emphasizing data described to regulate adipose differentiation, outside of those that are part of the canonical adipogenic transcriptional cascade.
Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3-L1 and 3T3-F442A during 1974-1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3-L1 and 3T3-F442A cells that have provided essential data on adipose biology.Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3-L1 and 3T3-F442A during 1974-1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3-L1 and 3T3-F442A cells that have provided essential data on adipose biology.
Author Kuri‐Harcuch, Walid
Velez‐delValle, Cristina
Vazquez‐Sandoval, Alfredo
Hernández‐Mosqueira, Claudia
Fernandez‐Sanchez, Veronica
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  surname: Vazquez‐Sandoval
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  surname: Fernandez‐Sanchez
  fullname: Fernandez‐Sanchez, Veronica
  organization: Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
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Issue 2
Keywords cell differentiation
staurosporine
adipogenesis
3T3-F442A
transcriptional regulation
adipocyte
3T3-L1
Language English
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Snippet Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism....
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SubjectTerms 3T3-L1 Cells
3T3‐F442A
3T3‐L1
adipocyte
Adipocytes
Adipocytes - metabolism
Adipogenesis
Adipogenesis - genetics
Animals
Cell culture
Cell differentiation
Cell lines
Cytoplasm
Differentiation (biology)
Energy metabolism
Fat metabolism
Gene regulation
Humans
Lipids
Metabolism
Mice
Secretion
Signal Transduction
staurosporine
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
transcriptional regulation
Title A cellular perspective of adipogenesis transcriptional regulation
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.27060
https://www.ncbi.nlm.nih.gov/pubmed/30146705
https://www.proquest.com/docview/2135600378
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Volume 234
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